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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1992-4-30
|
| pubmed:abstractText |
smg p21B/rap1B p21, a member of ras p21-like small GTP-binding protein superfamily, has been shown to be phosphorylated by cyclic AMP-dependent protein kinase (protein kinase A). We show here that this protein was also phosphorylated by cyclic GMP-dependent protein kinase (protein kinase G) in a cell-free system. The same serine residue (Ser179) in the C-terminal region was phosphorylated by both protein kinases G and A. The Km and Vmax values of smg p21B for protein kinase G were 5 x 10(-7) M and 4 x 10(-9) mol/min/mg, and those values for protein kinase A were 1 x 10(-7) M and 3 x 10(-8) mol/min/mg.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
297
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
171-4
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:1551424-Autoradiography,
pubmed-meshheading:1551424-Cell-Free System,
pubmed-meshheading:1551424-Chromatography, Liquid,
pubmed-meshheading:1551424-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1551424-GTP-Binding Proteins,
pubmed-meshheading:1551424-Phosphorylation,
pubmed-meshheading:1551424-Protein Kinases,
pubmed-meshheading:1551424-Proto-Oncogene Proteins,
pubmed-meshheading:1551424-rap GTP-Binding Proteins
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Phosphorylation of smg p21B/rap1B p21 by cyclic GMP-dependent protein kinase.
|
| pubmed:affiliation |
Department of Biochemistry, Kobe University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|