Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1992-4-29
|
pubmed:abstractText |
Population pharmacokinetic analysis of the anticancer agent epirubicin was carried out using the program NONMEM. Data were available from 36 patients aged 20-73 years, of whom 23 were women. All subjects exhibited normal liver and renal function. Epirubicin was given as a short-term i.v. infusion over the dose range of 25-100 mg/m2, and an average of 11 plasma samples/subject were taken for a period of up to 72 h after each dose. A Two compartment model was fitted to the data, characterised by the parameters clearance, volume of the central compartment, alpha and beta. Clearance was tested as a linear function of various demographic and/or biochemical features. A significant proportion of the variability in clearance could be attributed to sex, and also to age in women. For example, a 25-year-old man would display an average clearance of 95 l/h, whereas a 70-year-old woman would exhibit an average clearance of 64 l/h. Such differences in clearance might be important in the selection of epirubicin dose regimens.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0344-5704
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
29
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
391-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1551178-Adult,
pubmed-meshheading:1551178-Aged,
pubmed-meshheading:1551178-Aging,
pubmed-meshheading:1551178-Breast Neoplasms,
pubmed-meshheading:1551178-Chromatography, High Pressure Liquid,
pubmed-meshheading:1551178-Epirubicin,
pubmed-meshheading:1551178-Female,
pubmed-meshheading:1551178-Hodgkin Disease,
pubmed-meshheading:1551178-Humans,
pubmed-meshheading:1551178-Linear Models,
pubmed-meshheading:1551178-Male,
pubmed-meshheading:1551178-Middle Aged,
pubmed-meshheading:1551178-Models, Biological,
pubmed-meshheading:1551178-Sarcoma,
pubmed-meshheading:1551178-Sex Characteristics,
pubmed-meshheading:1551178-Time Factors
|
pubmed:year |
1992
|
pubmed:articleTitle |
Variability in the pharmacokinetics of epirubicin: a population analysis.
|
pubmed:affiliation |
Department of Medicine and Therapeutics, University of Glasgow, Gardiner Institute, Western Infirmary, UK.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|