Linked Life Data

15509223

Source:http://linkedlifedata.com/resource/pubmed/id/15509223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-10-28
pubmed:abstractText
Bone morphogenetic protein (BMP) molecules are members of a large family of signaling molecules important in numerous developmental pathways throughout the metazoa. Single members of the BMP2/4 class have been found in invertebrates such as cnidarians, arthropods, nematodes, echinoderms, ascidians, and cephalochordates. In all vertebrates studied, there are at least two copies, BMP2 and BMP4, that play important roles in axial patterning, tissue specification, and organogenesis. The basal vertebrate, lamprey, diverged near the time of vertebrate origins and is useful for understanding the gene duplication events that led to the increased complexity of the vertebrate genome. We characterized the sequence and expression pattern of BMP2/4 class genes in the sea lamprey, Petromyzon marinus. We uncovered three genes that we named PmBMP2/4A, PmBMP2/4B, and PmBMP2/4C. Phylogenetic analysis indicates that PmBMP2/4A is closer than PmBMP2/4B or PmBMP2/4C in sequence identity to both BMP2 and BMP4 of gnathostomes. The developmental expression pattern of PmBMP2/4A also more closely resembles the combined early expression patterns of gnathostome BMP2 and BMP4, whereas PmBMP2/4B and PmBMP2/4C appear to play roles only later in development. Cell labeling showed that the BMP-expressing cells in the branchial arches of lampreys are of neural crest origin. Taken together, our sequence and expression data support the duplication of BMP2/4 genes in the lamprey from a single ancestral vertebrate BMP2/4 gene.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1520-541X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Conservation and divergence of BMP2/4 genes in the lamprey: expression and phylogenetic analysis suggest a single ancestral vertebrate gene.
pubmed:affiliation
Division of Biology, MC 139-74, California Institute of Technology, Pasadena, CA 91125, USA. mccauley@gg.caltech.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.