Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Suppl 1
pubmed:dateCreated
2004-10-27
pubmed:abstractText
Hepatocellular carcinoma (HCC) is increasing in frequency in the United States. The age-adjusted incidence rates have doubled over the past 2 decades. Similar increases have affected the mortality and hospitalization rates. Although there has been a small recent improvement in survival, it remains generally dismal (median, 8 months). It is estimated that 8500 to 11,500 new cases of HCC occur annually in the United States. There are striking differences in the incidence of HCC related to age, gender, race, and geographic region. Although it remains an affliction of the elderly (mean age, 65 years) population, there has been a shift toward relatively younger age cases. Men are affected 3 times more frequently than women, Asians are affected 2 times more than blacks, and Hispanics are affected 2 times more often than whites. However, the recent increase has disproportionately affected white (and Hispanic) men between ages 45 and 65 years. The temporal changes of risk factors among HCC cases in the United States remain unclear. However, available studies indicate that hepatitis C virus (HCV) infection acquired 2-4 decades ago explains at least half of the observed increase in HCC; HCV-related HCC is likely to continue to increase for the next decade. A variable but significant proportion of cases (15% to 50%) do not have evidence of the risk factors of viral hepatitis or heavy alcohol consumption. The insulin resistance syndrome, manifesting as obesity and diabetes, is emerging as a risk factor for HCC in the United States; however, its impact on the current trend in HCC remains unclear.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S27-34
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed-meshheading:15508094-Adolescent, pubmed-meshheading:15508094-Adult, pubmed-meshheading:15508094-Age Factors, pubmed-meshheading:15508094-Aged, pubmed-meshheading:15508094-Alcohol Drinking, pubmed-meshheading:15508094-Carcinoma, Hepatocellular, pubmed-meshheading:15508094-Child, pubmed-meshheading:15508094-Child, Preschool, pubmed-meshheading:15508094-Female, pubmed-meshheading:15508094-Hepatitis C, pubmed-meshheading:15508094-Humans, pubmed-meshheading:15508094-Incidence, pubmed-meshheading:15508094-Infant, pubmed-meshheading:15508094-Infant, Newborn, pubmed-meshheading:15508094-Insulin Resistance, pubmed-meshheading:15508094-Liver Neoplasms, pubmed-meshheading:15508094-Male, pubmed-meshheading:15508094-Middle Aged, pubmed-meshheading:15508094-Risk Factors, pubmed-meshheading:15508094-Sex Factors, pubmed-meshheading:15508094-United States
pubmed:year
2004
pubmed:articleTitle
Hepatocellular carcinoma: recent trends in the United States.
pubmed:affiliation
The Houston Veterans Affairs Medical Center (152), 2002 Holcombe Boulevard, Houston, Texas 77030, USA. hasheme@bcm.tmc.edu
pubmed:publicationType
Journal Article, Review