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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1992-4-24
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pubmed:abstractText |
In leech, the central projections of peripheral sensory neurons segregate into specific axonal tracts, which are distinguished by differential expression of surface antigens recognized by the monoclonal antibodies Lan3-2 and Lan4-2. Lan3-2 recognizes an epitope expressed on axons that segregate into three distinct axon fascicles. In contrast, the Lan4-2-positive axons selectively project into only one of the Lan3-2-positive axon tracts. These observations provide evidence for a hierarchy of guidance cues mediating specific pathway formation in this system. Since the Lan3-2 antibody has been shown to perturb this process and since, as shown here, the Lan3-2 and Lan4-2 antigens are closely molecularly interrelated, these antibodies may help define molecules and epitopes mediating neuronal recognition and axonal guidance.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0896-6273
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1550678-Afferent Pathways,
pubmed-meshheading:1550678-Animals,
pubmed-meshheading:1550678-Antibodies, Monoclonal,
pubmed-meshheading:1550678-Axons,
pubmed-meshheading:1550678-Cell Differentiation,
pubmed-meshheading:1550678-Immunohistochemistry,
pubmed-meshheading:1550678-Leeches,
pubmed-meshheading:1550678-Nerve Tissue Proteins,
pubmed-meshheading:1550678-Peripheral Nerves
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pubmed:year |
1992
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pubmed:articleTitle |
Tract formation and axon fasciculation of molecularly distinct peripheral neuron subpopulations during leech embryogenesis.
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pubmed:affiliation |
Department of Zoology and Genetics, Iowa State University, Ames 50011.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|