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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-4-21
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pubmed:databankReference | |
pubmed:abstractText |
A cDNA specific for a human intestinal mucin (MLP) was amplified by PCR from cDNA of cultured human colonic adenocarcinoma cells, LS174T. The human cDNA shared high sequence homology with a corresponding rat intestinal mucin (MLP) cDNA in the 3' terminal region, and hybridized to the same mRNA (approximately 9.0 Kb) that was recognized by a probe for the MUC-2 human intestinal mucin gene. The gene encoding our human mucin peptide also mapped to chromosome 11 p 15.5, the known locus of MUC-2. Our findings suggest that human MLP and MUC-2 are encoded by the same gene and that rat and human intestinal mucin share a common C-terminal amino acid structure.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1550588-Adenocarcinoma,
pubmed-meshheading:1550588-Amino Acid Sequence,
pubmed-meshheading:1550588-Animals,
pubmed-meshheading:1550588-Base Sequence,
pubmed-meshheading:1550588-Chromosomes, Human, Pair 11,
pubmed-meshheading:1550588-Colonic Neoplasms,
pubmed-meshheading:1550588-DNA Mutational Analysis,
pubmed-meshheading:1550588-Humans,
pubmed-meshheading:1550588-Intestine, Small,
pubmed-meshheading:1550588-Molecular Sequence Data,
pubmed-meshheading:1550588-Mucins,
pubmed-meshheading:1550588-Nucleic Acid Hybridization,
pubmed-meshheading:1550588-Rats,
pubmed-meshheading:1550588-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1550588-Tumor Cells, Cultured
|
pubmed:year |
1992
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pubmed:articleTitle |
Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5.
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pubmed:affiliation |
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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