Source:http://linkedlifedata.com/resource/pubmed/id/15505112
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2004-11-26
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| pubmed:abstractText |
Endothelin-1 (ET-1) is a powerful vasconstrictor peptide implicated in development of essential hypertension and left ventricular hypertrophy. To evaluate the impact of genetic variability of the ET-1 gene on progression of blood pressure (BP) and left ventricular mass (LVM), we conducted individual growth curve modeling for 537 European American and black youths with 12 assessments during a 15-year period. Four common single-nucleotide polymorphisms (SNPs) including T-1370G, +138/ex1 del/ins, T-37/in2C, and Lys198Asn were included in this study. Single SNP analyses showed that individuals with the +138/ex1 ins allele had a borderline significant lower systolic BP (SBP; P=0.072). Furthermore, the -37/in2C allele showed an SBP-lowering effect in males, accounting for 1.6% between-subject variation of SBP (P=0.016). Haplotype analyses in males confirmed the BP-lowering effect of the -37/in2C allele. SBP in individuals homozygous for the del (+138/ex1) -C (-37/in2) haplotype was 3.3 mm Hg lower than those homozygous for the del (+138/ex1) -T (-37/in2) haplotype (P=0.038). For LVM, we observed a significant gene-environment interaction. LVM levels were 20 g higher in carriers versus noncarriers of the -1370G allele in the low socioeconomic status (SES) group only (P=0.004). In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1524-4563
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
884-90
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15505112-Adolescent,
pubmed-meshheading:15505112-African Continental Ancestry Group,
pubmed-meshheading:15505112-Blood Pressure,
pubmed-meshheading:15505112-Body Mass Index,
pubmed-meshheading:15505112-Child,
pubmed-meshheading:15505112-Cohort Studies,
pubmed-meshheading:15505112-Endothelin-1,
pubmed-meshheading:15505112-European Continental Ancestry Group,
pubmed-meshheading:15505112-Female,
pubmed-meshheading:15505112-Genotype,
pubmed-meshheading:15505112-Haplotypes,
pubmed-meshheading:15505112-Humans,
pubmed-meshheading:15505112-Hypertension,
pubmed-meshheading:15505112-Hypertrophy, Left Ventricular,
pubmed-meshheading:15505112-Linkage Disequilibrium,
pubmed-meshheading:15505112-Male,
pubmed-meshheading:15505112-Polymorphism, Single Nucleotide,
pubmed-meshheading:15505112-Risk Factors,
pubmed-meshheading:15505112-Sex Factors,
pubmed-meshheading:15505112-Socioeconomic Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youth.
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| pubmed:affiliation |
Georgia Prevention Institute Department of Pediatrics, Medical College of Georgia, Augusta 30912-3710, USA. ydong@mcg.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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