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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2004-11-2
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pubmed:abstractText |
Enhanced production of reactive oxygen species (ROS) has been recognized as the major determinant of age-related endothelial dysfunction. The p66shc protein controls cellular responses to oxidative stress. Mice lacking p66shc (p66shc-/-) have increased resistance to ROS and a 30% prolonged life span. The present study investigates age-dependent changes of endothelial function in this model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Shc Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Shc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BachschmidMarkusM,
pubmed-author:CosentinoFrancescoF,
pubmed-author:FranciaPietroP,
pubmed-author:LüscherThomas FelixTF,
pubmed-author:Martin-PaduraInesI,
pubmed-author:MigliaccioEnricaE,
pubmed-author:PelicciPier GiuseppePG,
pubmed-author:SavoiaCarmineC,
pubmed-author:SchiavoniMarziaM,
pubmed-author:VolpeMassimoM,
pubmed-author:delli GattiChiaraC
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2889-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15505103-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15505103-Aging,
pubmed-meshheading:15505103-Animals,
pubmed-meshheading:15505103-Aorta,
pubmed-meshheading:15505103-Endothelium, Vascular,
pubmed-meshheading:15505103-Isometric Contraction,
pubmed-meshheading:15505103-Longevity,
pubmed-meshheading:15505103-Male,
pubmed-meshheading:15505103-Mice,
pubmed-meshheading:15505103-Mice, Knockout,
pubmed-meshheading:15505103-Nitric Oxide,
pubmed-meshheading:15505103-Nitric Oxide Synthase,
pubmed-meshheading:15505103-Nitric Oxide Synthase Type II,
pubmed-meshheading:15505103-Nitric Oxide Synthase Type III,
pubmed-meshheading:15505103-Oxidative Stress,
pubmed-meshheading:15505103-Proteins,
pubmed-meshheading:15505103-Reactive Oxygen Species,
pubmed-meshheading:15505103-Shc Signaling Adaptor Proteins,
pubmed-meshheading:15505103-Superoxide Dismutase,
pubmed-meshheading:15505103-Tyrosine,
pubmed-meshheading:15505103-Vasoconstriction
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pubmed:year |
2004
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pubmed:articleTitle |
Deletion of p66shc gene protects against age-related endothelial dysfunction.
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pubmed:affiliation |
Cardiovascular Research & Cardiology, Institute of Physiology, Zürich, Irchel and University Hospital, Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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