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rdf:type |
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lifeskim:mentions |
umls-concept:C0001473,
umls-concept:C0014239,
umls-concept:C0015127,
umls-concept:C0017262,
umls-concept:C0036226,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0243144,
umls-concept:C0442802,
umls-concept:C0547047,
umls-concept:C0596235,
umls-concept:C0596981,
umls-concept:C1314792,
umls-concept:C2911684
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pubmed:issue |
23
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pubmed:dateCreated |
2004-12-7
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pubmed:abstractText |
Increasing sarcoplasmic/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) uptake activity is a promising therapeutic approach for heart failure. We investigated the effects of different levels of SERCA1a expression on contractility and Ca2+ cycling. We tested whether increased SERCA1a expression levels enhance myocyte contractility in a gene-dose-dependent manner.
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pubmed:grant |
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BersDonald MDM,
pubmed-author:CurrieSusanS,
pubmed-author:ElliottElspeth BEB,
pubmed-author:HasenfussGerdG,
pubmed-author:InesiGiuseppeG,
pubmed-author:KoglerHaraldH,
pubmed-author:PrestleJuergenJ,
pubmed-author:ReynoldsDeborah FDF,
pubmed-author:SchottPeterP,
pubmed-author:SeidlerTimT,
pubmed-author:SmithGodfrey LGL,
pubmed-author:TeucherNilsN,
pubmed-author:WagnerStefanS
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3553-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15505097-Adenoviridae,
pubmed-meshheading:15505097-Animals,
pubmed-meshheading:15505097-Calcium,
pubmed-meshheading:15505097-Calcium Signaling,
pubmed-meshheading:15505097-Calcium-Transporting ATPases,
pubmed-meshheading:15505097-Cell Size,
pubmed-meshheading:15505097-Cells, Cultured,
pubmed-meshheading:15505097-Gene Transfer Techniques,
pubmed-meshheading:15505097-Heart Ventricles,
pubmed-meshheading:15505097-Muscle Relaxation,
pubmed-meshheading:15505097-Myocardial Contraction,
pubmed-meshheading:15505097-Myocytes, Cardiac,
pubmed-meshheading:15505097-Rabbits,
pubmed-meshheading:15505097-Sarcoplasmic Reticulum,
pubmed-meshheading:15505097-Sarcoplasmic Reticulum Calcium-Transporting ATPases
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pubmed:year |
2004
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pubmed:articleTitle |
Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
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pubmed:affiliation |
Department of Cardiology and Pneumology, University of Goettingen, Goettingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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