rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0023440,
umls-concept:C0025166,
umls-concept:C0031437,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0964782,
umls-concept:C1257901,
umls-concept:C1414507,
umls-concept:C1423939,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2004-10-26
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pubmed:abstractText |
Two major protease-activated receptors (PARs), PAR1 and PAR4, are involved in the activation of human platelets by thrombin. A third, PAR3, is preferentially expressed by tissues of hematopoietic origin and megakaryocytes. Although PAR3 is also a thrombin substrate, its low-level expression on human platelets suggests a function distinct from that of PAR1, the major receptor involved in thrombin-mediated platelet activation. We studied the expression of PARs during megakaryocyte differentiation of human erythroleukemia (HEL) cells in order to determine the role of PAR3 in megakaryocytopoiesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Proteinase-Activated,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/protease-activated receptor 3
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0301-472X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
991-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15504554-Cell Differentiation,
pubmed-meshheading:15504554-Cell Line, Tumor,
pubmed-meshheading:15504554-Cell Lineage,
pubmed-meshheading:15504554-DNA,
pubmed-meshheading:15504554-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15504554-Humans,
pubmed-meshheading:15504554-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:15504554-Megakaryocytes,
pubmed-meshheading:15504554-RNA, Messenger,
pubmed-meshheading:15504554-Receptors, Cell Surface,
pubmed-meshheading:15504554-Receptors, Proteinase-Activated,
pubmed-meshheading:15504554-Receptors, Thrombin,
pubmed-meshheading:15504554-Signal Transduction,
pubmed-meshheading:15504554-Tetradecanoylphorbol Acetate,
pubmed-meshheading:15504554-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells.
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pubmed:affiliation |
Department of Medicine, State University of New York at Stony Brook, NY 11794-8151, USA. lcupit@notes.cc.sunysb.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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