Linked Life Data

15504343

Source:http://linkedlifedata.com/resource/pubmed/id/15504343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-10-26
pubmed:abstractText
Binding of di- or polyvalent cations is necessary to maintain the chromatin in isolated nuclei and metaphase chromosomes in a condensed state. We here show that the native, porous structure of the heterochromatin in the interphase nucleus requires both K(+) and Mg(2+) in concentrations, which are known to support transcription in isolated nuclei, thus providing a functional state of the chromatin. When these cations are acting separately, the chromatin is more condensed by Mg(2+) and decondensed by K(+). Comparison with published values of the free electrostatic energy of DNA in chromatin shows that this state of compaction is the result of a balance between the different aggregative properties of K(+) and Mg(2+) at a high degree of charge shielding.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
324
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1210-4
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Condensation of chromatin in situ by cation-dependent charge shielding and aggregation.
pubmed:affiliation
Department of Medical Biochemistry and Genetics,Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3c, 2200 Copenhagen N, Denmark. engelhardt@imbg.ku.dk
pubmed:publicationType
Journal Article