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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0013790,
umls-concept:C0015131,
umls-concept:C0015846,
umls-concept:C0024488,
umls-concept:C0026056,
umls-concept:C0033487,
umls-concept:C0086418,
umls-concept:C0442828,
umls-concept:C0563532,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1444748,
umls-concept:C1513492,
umls-concept:C1704632,
umls-concept:C1705994,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C2911692
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-4-23
|
| pubmed:abstractText |
The effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial stimulation (tc-MERs) were studied in five healthy human volunteers. Each subject, in four separate sessions, received intravenous bolus doses of propofol 2 mg.kg-1, etomidate 0.3 mg.kg-1, midazolam 0.05 mg.kg-1, and fentanyl 3 micrograms.kg-1. Electrical tc-MERs (tce-MERs) were elicited with anodal stimuli of 500-700 V. Magnetic tc-MERs (tcmag-MERs) were elicited using a Cadwell MES-10 magnetic stimulator at maximum output. Compound muscle action potentials were recorded from the tibialis anterior muscle. Duplicate tce-MERs and tcmag-MERs were recorded before and up to 30 min after drug injection. Reproducible baseline tce-MERs (amplitude 4.7 +/- 0.43 (SEM) mV, latency 29.4 +/- 0.35 ms) and tcmag-MERs (amplitude 3.7 +/- 0.43 mV, latency 31.1 +/- 0.39 ms) were obtained in all subjects. Pronounced depression of tce-MER amplitude to 2% of baseline values (P less than 0.01) was observed 2 min after injection of propofol. Thirty minutes after injection of propofol, amplitude depression to 44% of baseline (P less than 0.05) was still present, despite an apparent lack of sedation. Midazolam caused significant (P less than 0.01) amplitude depression, e.g., tcmag-MER to 16% of baseline values 5 min after injection. Significant depression persisted throughout the 30-min study period. Fentanyl did not cause any statistically significant amplitude changes in this small population. Etomidate caused significant but transient depression of tc-MER amplitude. However, there was considerable intersubject variability. Latency did not change significantly after any drug.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0003-3022
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
502-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1550274-Adult,
pubmed-meshheading:1550274-Electric Stimulation,
pubmed-meshheading:1550274-Etomidate,
pubmed-meshheading:1550274-Evoked Potentials,
pubmed-meshheading:1550274-Female,
pubmed-meshheading:1550274-Fentanyl,
pubmed-meshheading:1550274-Humans,
pubmed-meshheading:1550274-Injections, Intravenous,
pubmed-meshheading:1550274-Magnetics,
pubmed-meshheading:1550274-Male,
pubmed-meshheading:1550274-Midazolam,
pubmed-meshheading:1550274-Muscles,
pubmed-meshheading:1550274-Propofol
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial electrical or magnetic stimulation in humans.
|
| pubmed:affiliation |
University of California, San Diego.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|