Linked Life Data

1550240

Source:http://linkedlifedata.com/resource/pubmed/id/1550240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1992-4-23
pubmed:abstractText
Pancreatic polypeptide (PP) is released from pancreatic islets after meals or in response to stress. Although PP exhibits a wide spectrum of biological effects, few, if any, are mediated by a direct action of PP on its ultimate target organ. Recently, PP receptors have been identified in areas of the brain with an incomplete blood-brain barrier suggesting that PP may act indirectly through the central nervous system. In the present study, we sought to identify peripheral PP binding sites using an in vivo radioreceptor assay and in vitro autoradiography. Using these techniques, we have identified saturable binding sites for PP in the zona fasciculata, zona reticularis, and the medulla of the rat adrenal gland. We have characterized these sites using equilibrium analysis of membrane-radioligand binding and by quantitative autoradiography of radioligand binding to frozen tissue sections. Binding of PP to these sites is saturable, of high affinity, and specific as well as time, temperature, and membrane dependent. Moreover, PP binds to these putative receptor sites in vivo at physiological concentrations. Many of the actions of PPs have been demonstrated to be indirect. Because PP receptors have been identified in the brain and now in the adrenal gland, we suggest that some of the effects of PP may be mediated through direct and indirect modulation of the brain and adrenal axis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
262
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G532-6
pubmed:dateRevised
2008-8-20
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Localization and characterization of pancreatic polypeptide receptors in rat adrenal glands.
pubmed:affiliation
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.