Linked Life Data

1550045

Source:http://linkedlifedata.com/resource/pubmed/id/1550045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-4-23
pubmed:abstractText
Adrenalectomized rats were implanted with pellets containing corticosterone in proportions varying from 0% to 100%, plus cholesterol. Stable concentrations of plasma corticosterone resulted, varying from subnormal (A) to physiologic (B) to supraphysiologic (C). When food was ingested ad libitum, weight gain was maximal in B at plasma corticosterone concentrations of 0.14-0.20 mumol/L; weight loss occurred in C, despite higher food intake. Even when rats had constant limited food intake, weight gain and positive nitrogen balance were significantly reduced in A compared with B because fecal nitrogen rose significantly and the retention of absorbed nitrogen for growth decreased. In C, weight decreased despite constant intake, and nitrogen balance became negative because urinary nitrogen increased markedly. We conclude that glucocorticoid insufficiency reduces nitrogen balance by impairing intestinal absorption of dietary protein and the utilization of absorbed nitrogen, whereas glucocorticoid excess reduces nitrogen balance by augmenting urinary nitrogen despite constant nitrogen intake.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
695-700
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Effects of corticosterone administration on nitrogen excretion and nitrogen balance in adrenalectomized rats.
pubmed:affiliation
Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.