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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-10-25
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pubmed:abstractText |
Several thiazolyl/benzothiazolyl/benzo[d]isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64%). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,2-diphenyl-1-picrylhydrazyl,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethyl Sulfoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyl Radical,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Picrates,
http://linkedlifedata.com/resource/pubmed/chemical/Schiff Bases,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiosemicarbazones
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pubmed:status |
MEDLINE
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pubmed:issn |
0004-4172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15500199-Animals,
pubmed-meshheading:15500199-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15500199-Antioxidants,
pubmed-meshheading:15500199-Biphenyl Compounds,
pubmed-meshheading:15500199-Carrageenan,
pubmed-meshheading:15500199-Chemistry, Physical,
pubmed-meshheading:15500199-Dimethyl Sulfoxide,
pubmed-meshheading:15500199-Edema,
pubmed-meshheading:15500199-Female,
pubmed-meshheading:15500199-Free Radical Scavengers,
pubmed-meshheading:15500199-Hydroxyl Radical,
pubmed-meshheading:15500199-Indicators and Reagents,
pubmed-meshheading:15500199-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15500199-Male,
pubmed-meshheading:15500199-Mice,
pubmed-meshheading:15500199-Mice, Inbred AKR,
pubmed-meshheading:15500199-Physicochemical Phenomena,
pubmed-meshheading:15500199-Picrates,
pubmed-meshheading:15500199-Pregnancy,
pubmed-meshheading:15500199-Quantitative Structure-Activity Relationship,
pubmed-meshheading:15500199-Schiff Bases,
pubmed-meshheading:15500199-Spectrophotometry, Infrared,
pubmed-meshheading:15500199-Thiazoles,
pubmed-meshheading:15500199-Thiosemicarbazones
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pubmed:year |
2004
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pubmed:articleTitle |
Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities.
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pubmed:affiliation |
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece. geronik@pharm.auth.gr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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