| pubmed-article:15499654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0450048 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0009498 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C1439287 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C1420464 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15499654 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:15499654 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15499654 | pubmed:dateCreated | 2004-11-1 | lld:pubmed |
| pubmed-article:15499654 | pubmed:abstractText | The function of Aurora-C kinase, a member of the Aurora kinase family identified in mammals, is currently unknown. We present evidence that Aurora-C, like Aurora-B kinase, is a chromosomal passenger protein localizing first to centromeres and then to the midzone of mitotic cells. Aurora-C transcript is expressed at a moderate level albeit about an order of magnitude lower than Aurora-B transcript in diploid human fibroblasts. The level of Aurora-C transcript is elevated in several human cancer cell types. Aurora-C and Aurora-B mRNA and protein expressions are maximally elevated during the G2/M phase but their expression profiles in synchronized cells reveal differential temporal regulation through the cell cycle with Aurora-C level peaking after that of Aurora-B during the later part of the M phase. Aurora-C, like Aurora-B, interacts with the inner centromere protein (INCENP) at the carboxyl terminal end spanning the conserved IN box domain. Competition binding assays and transfection experiments revealed that, compared with Aurora-C, Aurora-B has preferential binding affinity to INCENP and co-expression of the two in vivo interferes with INCENP binding, localization, and stability of these proteins. A kinase-dead mutant of Aurora-C had a dominant negative effect inducing multinucleation in a dose-dependent manner. siRNA mediated silencing of Aurora-C and Aurora-B also gave rise to multinucleated cells with the two kinases silenced at the same time displaying an additive effect. Finally, Aurora-C could rescue the Aurora-B silenced multinucleation phenotype, demonstrating that Aurora-C kinase function overlaps with and complements Aurora-B kinase function in mitosis. | lld:pubmed |
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| pubmed-article:15499654 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15499654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15499654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15499654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15499654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15499654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15499654 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15499654 | pubmed:issn | 0886-1544 | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:EarnshawWilli... | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:OkanoYukioY | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:KimuraMasashi... | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:SenSubrataS | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:SuzukiFumioF | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:HondaReikoR | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:NiggErich AEA | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:FujiiSatoshiS | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:SasaiKaoriK | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:KatayamaHiros... | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:TatsukaMasaak... | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:StenoienDavid... | lld:pubmed |
| pubmed-article:15499654 | pubmed:author | pubmed-author:BrinkleyWilli... | lld:pubmed |
| pubmed-article:15499654 | pubmed:copyrightInfo | 2004 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15499654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15499654 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:15499654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15499654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15499654 | pubmed:pagination | 249-63 | lld:pubmed |
| pubmed-article:15499654 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
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| pubmed-article:15499654 | pubmed:meshHeading | pubmed-meshheading:15499654... | lld:pubmed |
| pubmed-article:15499654 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15499654 | pubmed:articleTitle | Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. | lld:pubmed |
| pubmed-article:15499654 | pubmed:affiliation | Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:15499654 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15499654 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15499654 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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