Rheumatoid arthritis (RA) synovium is characterised by enhanced NF-kappaB activity and proinflammatory cytokines. Cryopyrin (CIAS-1, NALP-3, PYPAF-1) has been shown to regulate NF-kappaB and caspase-1 activation.
Division of Rheumatology, Allergy and Immunology, Department of Medicine, UCSD School of Medicine, 0656, 9500 Gilman Drive, La Jolla California 92093-0656, USA.