Linked Life Data

15496535

Source:http://linkedlifedata.com/resource/pubmed/id/15496535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-10-21
pubmed:abstractText
The steroid hydroxylase CYP3A4 is the most abundant P-450 enzyme in the human liver, and CYP3A enzymes metabolize more than 50% of prescription drugs. The CYP3A4 gene is expressed in the liver, gut, colon, prostate, and breast. Individual variation in CYP3A4 may play a role in breast and prostate carcinogenesis through modulation of sex hormone metabolite levels. Alternatively, CYP3A4 can metabolically activate exogenous carcinogens. CYP3A4 activity varies widely in humans, and more than 78 DNA sequence polymorphisms are known. These observations prompted the hypothesis that variant CYP3A4 may be involved in breast and prostate cancer. Two epidemiologic studies of breast cancer and five of prostate cancer examined CYP3A4 genotypes. A US study showed that inheritance of CYP3A4*1B correlates with early menarche, a breast cancer risk factor. However, an Australian breast cancer case-control study found no association with CYP3A4*1B. Two Scottish prospective studies showed CYP3A4*1B to be a risk factor for prostate cancer among men with benign prostatic hyperplasia. Three other studies were undertaken in the United States: two were case-only studies and the other was a case-sibling control study. Although results for African Americans were inconsistent, these studies suggested that CYP3A4*1B was associated with markers of advanced disease. These observations support the notion that development of robust, conventional molecular epidemiologic case-control studies to address these questions, including gene-gene and gene-environment interactions, will be timely.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-41
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15496535-African Americans, pubmed-meshheading:15496535-Androgens, pubmed-meshheading:15496535-Australia, pubmed-meshheading:15496535-Breast Neoplasms, pubmed-meshheading:15496535-Carcinogens, pubmed-meshheading:15496535-Case-Control Studies, pubmed-meshheading:15496535-Cytochrome P-450 CYP3A, pubmed-meshheading:15496535-Cytochrome P-450 Enzyme System, pubmed-meshheading:15496535-Epidemiologic Studies, pubmed-meshheading:15496535-Female, pubmed-meshheading:15496535-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15496535-Gene Frequency, pubmed-meshheading:15496535-Genetic Predisposition to Disease, pubmed-meshheading:15496535-Genetic Variation, pubmed-meshheading:15496535-Genotype, pubmed-meshheading:15496535-Humans, pubmed-meshheading:15496535-Male, pubmed-meshheading:15496535-Molecular Epidemiology, pubmed-meshheading:15496535-Polymorphism, Genetic, pubmed-meshheading:15496535-Prevalence, pubmed-meshheading:15496535-Prospective Studies, pubmed-meshheading:15496535-Prostatic Neoplasms, pubmed-meshheading:15496535-Risk Factors, pubmed-meshheading:15496535-Scotland, pubmed-meshheading:15496535-Sequence Analysis, DNA, pubmed-meshheading:15496535-United States
pubmed:year
2004
pubmed:articleTitle
CYP3A4 polymorphisms--potential risk factors for breast and prostate cancer: a HuGE review.
pubmed:affiliation
Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA.
pubmed:publicationType
Journal Article, Review