Linked Life Data

15496292

Source:http://linkedlifedata.com/resource/pubmed/id/15496292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2004-10-21
pubmed:abstractText
The plant polyphenol quercetin was shown to induce Cl- secretion in rat colon. This study was performed to investigate the alterations of membrane conductances in isolated epithelial cells induced by quercetin. Whole-cell patch-clamp recordings were performed in isolated crypts from rat distal colon. In cells of the crypt basis, quercetin significantly hyperpolarized the membrane potential at concentrations > or =3 microM and increased the K+ conductance without visibly altering the Cl- conductance. Thus, quercetin induces Cl- secretion merely by activation of K+ channels in the colon epithelium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
503
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effect of the flavonol quercetin on membrane conductances in rat colonic crypt cells.
pubmed:affiliation
Institute of Animal Nutrition and Physiology, Christian-Albrechts-University of Kiel, Olshausenstr. 40, D-24098 Kiel, Germany. cermak@aninut.uni-kiel.de
pubmed:publicationType
Journal Article, In Vitro