15496222

Source:http://linkedlifedata.com/resource/pubmed/id/15496222

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001554, umls-concept:C0006982, umls-concept:C0020259, umls-concept:C0023570, umls-concept:C0030567, umls-concept:C0030705, umls-concept:C0031809, umls-concept:C0036043, umls-concept:C0178602, umls-concept:C0201734, umls-concept:C0205420, umls-concept:C0392747, umls-concept:C0439064, umls-concept:C0442027, umls-concept:C0527316
pubmed:dateCreated	2004-10-21
pubmed:abstractText	The use of acetylcholinesterase inhibitors for the treatment of comorbid Alzheimer's disease in Parkinson's disease (PD) patients stabilized on a levodopa regimen may potentially disrupt cholinergic balance. This randomized, double-blind, crossover study investigated the safety of, and possible drug-drug interaction between, donepezil HCl and levodopa/carbidopa.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503323
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents, http://linkedlifedata.com/resource/pubmed/chemical/Carbidopa, http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations, http://linkedlifedata.com/resource/pubmed/chemical/Indans, http://linkedlifedata.com/resource/pubmed/chemical/Levodopa, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/donepezil
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0306-5251
pubmed:author	pubmed-author:CullenEdward IEI, pubmed-author:HahneWilliam AWA, pubmed-author:KirbyLouisL, pubmed-author:KumarDineshD, pubmed-author:OkerekeChukwuemeka SCS, pubmed-author:PrattRaymond DRD
pubmed:issnType	Print
pubmed:volume	58 Suppl 1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	41-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15496222-Aged, pubmed-meshheading:15496222-Aged, 80 and over, pubmed-meshheading:15496222-Antiparkinson Agents, pubmed-meshheading:15496222-Carbidopa, pubmed-meshheading:15496222-Cholinesterase Inhibitors, pubmed-meshheading:15496222-Cross-Over Studies, pubmed-meshheading:15496222-Double-Blind Method, pubmed-meshheading:15496222-Drug Combinations, pubmed-meshheading:15496222-Drug Interactions, pubmed-meshheading:15496222-Female, pubmed-meshheading:15496222-Humans, pubmed-meshheading:15496222-Indans, pubmed-meshheading:15496222-Levodopa, pubmed-meshheading:15496222-Male, pubmed-meshheading:15496222-Middle Aged, pubmed-meshheading:15496222-Parkinson Disease, pubmed-meshheading:15496222-Piperidines
pubmed:year	2004
pubmed:articleTitle	Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses.
pubmed:affiliation	Clinical Pharmacology, Eisai Medical Research Inc., Ridgefield Park, NJ 07660, USA. chuk_okereke@eisai.com
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial