|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007589,
umls-concept:C0007776,
umls-concept:C0010592,
umls-concept:C0022646,
umls-concept:C0022655,
umls-concept:C0035015,
umls-concept:C0035696,
umls-concept:C0205191,
umls-concept:C0600688,
umls-concept:C0936012,
umls-concept:C1511938,
umls-concept:C1548437,
umls-concept:C1882923
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2004-10-21
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|
pubmed:abstractText |
In kidney transplantation, chronic allograft nephropathy (CAN) is the major cause of graft loss. Causes of CAN include chronic rejection and chronic cyclosporine A (CsA) nephrotoxicity. It is necessary to differentiate between these two entities in order to apply the appropriate therapeutic regimen for the individual patient, but this is hampered by the lack of discriminating functional and morphologic parameters. We investigated whether renal cortical mRNA levels for several matrix proteins can serve as discriminating parameters.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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|
pubmed:issn |
0085-2538
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
66
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2038-46
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pubmed:dateRevised |
2009-5-12
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pubmed:meshHeading |
pubmed-meshheading:15496177-Adult,
pubmed-meshheading:15496177-Chronic Disease,
pubmed-meshheading:15496177-Cyclosporine,
pubmed-meshheading:15496177-Diagnosis, Differential,
pubmed-meshheading:15496177-Extracellular Matrix Proteins,
pubmed-meshheading:15496177-Female,
pubmed-meshheading:15496177-Graft Rejection,
pubmed-meshheading:15496177-Humans,
pubmed-meshheading:15496177-Immunohistochemistry,
pubmed-meshheading:15496177-Kidney,
pubmed-meshheading:15496177-Kidney Cortex,
pubmed-meshheading:15496177-Kidney Transplantation,
pubmed-meshheading:15496177-Laminin,
pubmed-meshheading:15496177-Male,
pubmed-meshheading:15496177-Middle Aged,
pubmed-meshheading:15496177-Poisoning,
pubmed-meshheading:15496177-RNA, Messenger,
pubmed-meshheading:15496177-ROC Curve,
pubmed-meshheading:15496177-Staining and Labeling,
pubmed-meshheading:15496177-Transforming Growth Factor beta
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Differentiation between chronic rejection and chronic cyclosporine toxicity by analysis of renal cortical mRNA.
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pubmed:affiliation |
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. k.koop@lumc.nl
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pubmed:publicationType |
Journal Article
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