15496061

Source:http://linkedlifedata.com/resource/pubmed/id/15496061

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014630, umls-concept:C0220781, umls-concept:C0243071, umls-concept:C0441655, umls-concept:C0596087, umls-concept:C0960892, umls-concept:C1706853, umls-concept:C1879748, umls-concept:C1883254, umls-concept:C2603343
pubmed:issue	22
pubmed:dateCreated	2004-10-21
pubmed:abstractText	[reaction: see text] A series of structurally simplified luminacin analogues devoid of the epoxide ring are assembled in a stereocontrolled manner from 2,4-dimethoxybenzaldehyde using a syn-selective aldol reaction as the key step. The success of the approach is critically dependent on the nature and extent of the alcohol protecting groups. The synthetic analogues inhibit VEGF-stimulated angiogenesis in an in vitro assay indicating that the epoxide is not essential for biological activity in this compound class.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100890393
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Oct
pubmed:issn	1523-7060
pubmed:author	pubmed-author:DaviesMark WMW, pubmed-author:MaskellLesleyL, pubmed-author:ShipmanMichaelM, pubmed-author:SlawinAlexandra M ZAM, pubmed-author:VidotSandrine M ESM, pubmed-author:WhatmoreJacqueline LJL
pubmed:issnType	Print
pubmed:day	28
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3909-12
pubmed:year	2004
pubmed:articleTitle	Studies toward the synthesis of luminacin D: assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity.
pubmed:affiliation	Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
pubmed:publicationType	Journal Article