|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1992-4-17
|
|
pubmed:abstractText |
The pseudoautosomal (PA) region of the mammalian genome is the region of the X and Y chromosomes that shares extensive DNA sequence homology and is of special interest because it may play an essential role during male meiosis. We have identified three telomere-related restriction fragments from the PA region of the mouse genome, using an oligonucleotide probe composed of the mammalian telomere consensus sequence TTAGGG. PA assignment of two C57BL/6J-derived fragments was initially suggested by analysis of DNAs from progeny sired by C57BL/6J males carrying the rearranged Y chromosome, Y*: the hybridization intensity of both fragments was concordant with the sex-chromosome complement of the offspring. Further analysis indicated that both fragments were present in female and male F1, mice regardless of the sex of their C57BL/6J parent--a criterion for autosomal or PA linkage. Both fragments were closely linked to each other and located on the X chromosome distal to amelogenin (Amg)--in agreement with X or PA linkage. Confirmation of the PA derivation of these fragments was accomplished by following their segregation in a cross involving XY* males mated to DBA/2J females. A similar experiment identified a third PA-derived restriction fragment of LT/SvEi origin. Identification of PA-derived telomere-related restriction fragments will enable further genetic analysis of this region of the mouse genome.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-1675194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-1686839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-1708110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-1743079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-1743080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2068781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2129288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2170845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2272501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2414013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2425262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2696184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-273256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2737677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2780561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2847915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2895727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2899541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2906327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-2937147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3004966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3025741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3413114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3475232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3478692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3503725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3582977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3622012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3858674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-3941746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-4015654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-4059056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-5156366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-6139813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-6890629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-7129448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1549575-881736
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2160-4
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1549575-Animals,
pubmed-meshheading:1549575-Base Sequence,
pubmed-meshheading:1549575-Blotting, Southern,
pubmed-meshheading:1549575-Crosses, Genetic,
pubmed-meshheading:1549575-DNA,
pubmed-meshheading:1549575-DNA Probes,
pubmed-meshheading:1549575-Female,
pubmed-meshheading:1549575-Genetic Linkage,
pubmed-meshheading:1549575-Genetic Markers,
pubmed-meshheading:1549575-Heterochromatin,
pubmed-meshheading:1549575-Male,
pubmed-meshheading:1549575-Mice,
pubmed-meshheading:1549575-Mice, Inbred Strains,
pubmed-meshheading:1549575-Muridae,
pubmed-meshheading:1549575-Oligonucleotide Probes,
pubmed-meshheading:1549575-Recombination, Genetic,
pubmed-meshheading:1549575-Telomere,
pubmed-meshheading:1549575-X Chromosome,
pubmed-meshheading:1549575-Y Chromosome
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Telomere-related markers for the pseudoautosomal region of the mouse genome.
|
|
pubmed:affiliation |
Jackson Laboratory, Bar Harbor, ME 04609.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
