Linked Life Data

1549546

Source:http://linkedlifedata.com/resource/pubmed/id/1549546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-21
pubmed:abstractText
Pharmacokinetic studies of lithium and tricyclic antidepressants (TCAs) in children and adolescents report similarities to adults with respect to a wide interindividual genetic variation in the rate of elimination and with regard to the linear nature of the system. Children may eliminate these medications more rapidly; therefore, more frequent dosing may be necessary to maintain steady state serum lithium or plasma TCA levels. Doses of these medications necessary for desired blood levels can be obtained from tables based on nomograms (i.e., one-step dosage adjustment determined from a single serum lithium or plasma TCA level drawn 24 hours after administration of a single dose). Use of these dose prediction tables avoids toxicity due to excessively high blood levels in genetically slow metabolizers in whom medication regimes that use mg/kg dose schedules may produce toxic blood levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0193-953X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Lithium and tricyclic antidepressants.
pubmed:affiliation
Washington University School of Medicine, St. Louis, Missouri.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review