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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-4-20
|
| pubmed:abstractText |
The majority of follicular lymphoma cells carry the typical chromosome translocation 14;18, which juxtaposes the bcl-2 gene to the immunoglobulin heavy-chain (IgH) gene. Variant translocations of the bcl-2 gene to the Ig lambda or Ig kappa gene have been found by molecular biological techniques in a significant fraction (approximately 10%) of chronic lymphocytic leukemia (CLL). However, there have been no reports describing the presence of cytogenetic 18;22 and 2;18 translocations in CLL, in spite of extensive karyotypic studies. We present here two cases of CLL, one with cytogenetically detected t(2;18)(p11;q21) and the other with the t(18;22)(q21;q11). The molecular analysis revealed that these translocations juxtaposed the bcl-2 and immunoglobulin light-chain (IgL) genes. The t(18;22) broke the 5' flanking region of the bcl-2 gene and juxtaposed to the immunoglobulin lambda light-chain (Ig lambda) gene in a head-to-head configuration, as in the cases previously described. In the case of the t(2;18), the bcl-2 gene and immunoglobulin kappa light-chain (Ig kappa) gene were juxtaposed in a head-to-tail configuration, which is opposite to that expected from the orientation of the genes on chromosomes. The breakpoint was located within the 5' untranslated region of the bcl-2 gene. The results presented here indicate that the bcl-2/immunoglobulin light-chain (IgL) gene juxtaposition seen in a fraction of CLL is the result of cytogenetically detectable reciprocal chromosome translocations 2;18 and 18;22.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
bcl-2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
573-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1549371-Base Sequence,
pubmed-meshheading:1549371-Chromosome Aberrations,
pubmed-meshheading:1549371-Chromosome Disorders,
pubmed-meshheading:1549371-Chromosomes, Human, Pair 18,
pubmed-meshheading:1549371-Chromosomes, Human, Pair 2,
pubmed-meshheading:1549371-Chromosomes, Human, Pair 22,
pubmed-meshheading:1549371-Cloning, Molecular,
pubmed-meshheading:1549371-Genes, Immunoglobulin,
pubmed-meshheading:1549371-Humans,
pubmed-meshheading:1549371-Immunoglobulin Light Chains,
pubmed-meshheading:1549371-Karyotyping,
pubmed-meshheading:1549371-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:1549371-Molecular Sequence Data,
pubmed-meshheading:1549371-Proto-Oncogene Proteins,
pubmed-meshheading:1549371-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:1549371-Translocation, Genetic
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Cytogenetic 2; 18 and 18; 22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes.
|
| pubmed:affiliation |
Department of Hematology, School of Medicine, Hiroshima University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|