| pubmed-article:1549358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1549358 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1549358 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1549358 | pubmed:dateCreated | 1992-4-20 | lld:pubmed |
| pubmed-article:1549358 | pubmed:abstractText | We have undertaken a detailed analysis of the cis-acting elements that are required for optimal transcription initiation from P2, the major promoter of the murine c-myc gene. We find that three elements contribute to promoter strength, termed ME1a2, E2F and ME1a1 at positions -85, -64 and -46 respectively (relative to P2). Individually the elements are weak, but combined they contribute to full promoter activity, all acting in a positive fashion. The E2F element is the site at which the SV40 large T antigen transactivates the c-myc promoter. However, transactivation requires the presence of the ME1a2 or ME1a1 elements in addition to E2F. By a number of criteria it appears that the ME1a2 and ME1a1 elements bind the same or a very closely related protein (monomer Mr 94,000). It was found that Hela cells contain a novel factor that is capable of binding to the ME1a1 and ME1a2 elements but only in the presence of the protein-dissociating agents deoxycholate or formamide. Finally, the E2F factor binds DNA both as a monomer and as a multiprotein complex; the latter is cell type specific. Both types of bound E2F factor form less stable protein-DNA complexes than the ME1a2/ME1a1 factor. | lld:pubmed |
| pubmed-article:1549358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1549358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1549358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1549358 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1549358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1549358 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1549358 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:1549358 | pubmed:author | pubmed-author:HallD JDJ | lld:pubmed |
| pubmed-article:1549358 | pubmed:author | pubmed-author:MobergK HKH | lld:pubmed |
| pubmed-article:1549358 | pubmed:author | pubmed-author:TyndallW AWA | lld:pubmed |
| pubmed-article:1549358 | pubmed:author | pubmed-author:LoganT JTJ | lld:pubmed |
| pubmed-article:1549358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1549358 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:1549358 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:1549358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1549358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1549358 | pubmed:pagination | 411-21 | lld:pubmed |
| pubmed-article:1549358 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1549358 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1549358 | pubmed:articleTitle | Three distinct elements within the murine c-myc promoter are required for transcription. | lld:pubmed |
| pubmed-article:1549358 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107. | lld:pubmed |
| pubmed-article:1549358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1549358 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1549358 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1549358 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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