Linked Life Data

15493271

Source:http://linkedlifedata.com/resource/pubmed/id/15493271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-10-20
pubmed:abstractText
Experimental autoimmune thyroiditis (EAT) induced by immunization of susceptible (H-2k) mice can be significantly suppressed by pretreatment with soluble mouse thyroglobulin administered intravenously. Lightly irradiated recipients of spleen cells from donors pretreated in this way show a reduced response when subsequently challenged with mouse thyroglobulin and adjuvant (Kong et al., 1982; Parish et al., 1988). Previous studies on the SJL mouse revealed, among other abnormalities, a lack of suppressor cells (Cooke & Hutchings, 1984; Hutchings, Varey & Cooke, 1986; Amagai & Cinader, 1981) and therefore tolerance induction to mouse thyroglobulin and subsequent transfer was examined in these animals. The SJL mouse could be tolerized by i.v. administration of mouse thyroglobulin, but transfer of spleen cells from these animals failed to mediate suppression in syngeneic recipients. Several congenic strains of B10 mice showed similar 'in situ' tolerance without subsequent successful transfer and we conclude that the tolerance system described may be mediated by two distinct pathways and that the SJL appears to be defective only in the second pathway. Studies on other mouse strains suggest that the ability to be tolerized or to transfer tolerance is not dependent on a particular H-2 or I-E.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-2450834, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-2947846, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-3113790, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-363285, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-5133731, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-5135623, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6174416, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6185613, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6215879, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6230309, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6791162, http://linkedlifedata.com/resource/pubmed/commentcorrection/15493271-6792424
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Abnormalities in the SJL mouse provide evidence for different mechanisms for the induction and transfer of tolerance to mouse thyroglobulin.
pubmed:affiliation
Department of Immunology, Middlesex Hospital Medical School, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't