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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-11-3
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pubmed:abstractText |
One of the two X chromosomes becomes inactivated during early development of female mammals. Recent studies demonstrate that the inactive X chromosome is rich in histone H3 methylated at Lys-9 and Lys-27, suggesting an important role for these modifications in X-inactivation. It has been shown that in the mouse Eed is required for maintenance of X-inactivation in the extraembryonic lineages. Interestingly, Eed associates with Ezh2 to form a complex possessing histone methyltransferase activity predominantly for H3 Lys-27. We previously showed that G9a is one of the histone methyltransferases specific for H3 Lys-9 and is essential for embryonic development. Here we examined X-inactivation in mouse embryos deficient for G9a. Expression of Xist, which is crucial for the initiation of X-inactivation, was properly regulated and the inactivated X chromosome was stably maintained even in the absence of G9a. These results demonstrate that G9a is not essential for X-inactivation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1526-954X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15493016-Animals,
pubmed-meshheading:15493016-Crosses, Genetic,
pubmed-meshheading:15493016-Dosage Compensation, Genetic,
pubmed-meshheading:15493016-Embryo, Mammalian,
pubmed-meshheading:15493016-Female,
pubmed-meshheading:15493016-Gene Targeting,
pubmed-meshheading:15493016-Green Fluorescent Proteins,
pubmed-meshheading:15493016-Histone-Lysine N-Methyltransferase,
pubmed-meshheading:15493016-Homozygote,
pubmed-meshheading:15493016-Humans,
pubmed-meshheading:15493016-Male,
pubmed-meshheading:15493016-Methylation,
pubmed-meshheading:15493016-Mice,
pubmed-meshheading:15493016-Mice, Inbred C57BL,
pubmed-meshheading:15493016-Mice, Knockout,
pubmed-meshheading:15493016-Mice, Transgenic,
pubmed-meshheading:15493016-Protein Methyltransferases,
pubmed-meshheading:15493016-RNA, Untranslated,
pubmed-meshheading:15493016-X Chromosome
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pubmed:year |
2004
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pubmed:articleTitle |
X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a.
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pubmed:affiliation |
PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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