| pubmed-article:15492236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C0027022 | lld:lifeskim |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C0071253 | lld:lifeskim |
| pubmed-article:15492236 | lifeskim:mentions | umls-concept:C1708111 | lld:lifeskim |
| pubmed-article:15492236 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:15492236 | pubmed:dateCreated | 2004-10-19 | lld:pubmed |
| pubmed-article:15492236 | pubmed:abstractText | We describe the fusion of TP53BP1 to PDGFRB in a patient with a chronic myeloid leukemia-like disorder associated with eosinophilia and a t(5;15)(q33;q22). TP53BP1 encodes 53BP1, a p53-binding protein that plays a role in cellular responses to DNA damage. The 53BP1-PDGFRbeta fusion protein is predicted to retain the kinetochore-binding domain of 53BP1 fused to the transmembrane and intracellular tyrosine kinase domain of PDGFRbeta. The presence of the fusion was confirmed by two-color fluorescence in situ hybridization, reverse transcription-PCR, and by characterizing the genomic breakpoints. The reciprocal fusion, which would contain the p53-binding 53BP1 BRCA1 COOH-terminal domains, was not detectable by fluorescence in situ hybridization or nested PCR. Imatinib, a known inhibitor of PDGFRbeta, blocked the growth of patient colony-forming unit, granulocyte-macrophage in vitro and produced a clinically significant response before relapse and subsequent death with imatinib-resistant disease. We conclude that TP53BP1-PDGFRB is a novel imatinib target in atypical chronic myeloid leukemia. | lld:pubmed |
| pubmed-article:15492236 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15492236 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15492236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15492236 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15492236 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:KührThomasT | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:ThalerJosefJ | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:CrossNicholas... | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:BaxterE... | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:WebersinkeGer... | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:GrandFrancis... | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:ChaseAndrew... | lld:pubmed |
| pubmed-article:15492236 | pubmed:author | pubmed-author:BurgstallerSo... | lld:pubmed |
| pubmed-article:15492236 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15492236 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15492236 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:15492236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15492236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15492236 | pubmed:pagination | 7216-9 | lld:pubmed |
| pubmed-article:15492236 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15492236 | pubmed:meshHeading | pubmed-meshheading:15492236... | lld:pubmed |
| pubmed-article:15492236 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15492236 | pubmed:articleTitle | p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. | lld:pubmed |
| pubmed-article:15492236 | pubmed:affiliation | Wessex Regional Genetics Laboratory, Salisbury and Human Genetics Division, University of Southampton, Southampton, United Kingdom. | lld:pubmed |
| pubmed-article:15492236 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15492236 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:15492236 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15492236 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15492236 | lld:pubmed |
