Linked Life Data

15491782

Source:http://linkedlifedata.com/resource/pubmed/id/15491782

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-10-19
pubmed:abstractText
During mechanical ventilation the lungs are exposed to substantial physical forces. This is particularly true for patients with acute lung injury, where the applied pressures are two to three times higher than those present during normal breathing. The resultant overdistension activates specific mechanotransduction pathways, many of which activate inflammation pathways that might lead to (further) acute lung injury. In this article, we review evidence suggesting that pharmacological strategies can interfere with ventilator-induced lung injury at different stages of the inflammatory cascade: blockade of transcription factors, neutralization of chemokines, cytokines and neuropeptides, and inhibition of proteases. These findings provide rationale for the use of anti-inflammatory therapies to treat the side-effects of mechanical ventilation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
592-600
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Pharmacological interventions in ventilator-induced lung injury.
pubmed:affiliation
Division of Pulmonary Pharmacology, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany. suhlig@fz-borstel.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't