Linked Life Data

15491586

Source:http://linkedlifedata.com/resource/pubmed/id/15491586

Statements in which the resource exists.
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pubmed-article:15491586pubmed:abstractTextThis study investigated associations between pre-treatment cytokine expression and infection patterns, before and after de-worming, in humans exposed to two gastrointestinal nematode species. Quantitative measures of Ascaris lumbricoides and Trichuris trichiura infection (based on faecal egg counts) were estimated immediately before and 8-9 months after treatment in a Cameroonian population. Whole blood cytokine responses to parasite-derived antigens were assayed immediately pre-treatment. An overall measure of the tendency towards species-specific infection (increasing with A. lumbricoides faecal egg counts and decreasing with T. trichiura faecal egg counts) was significantly positively related to IL-10 levels in older (14-57 year) hosts. There was a significant negative influence of IL-5 on reinfection probability in T. trichiura but not A. lumbricoides. This effect coincided with reduced reinfection success in T. trichiura compared to A. lumbricoides. T(H)2 cytokine expression by younger hosts (4-13 year) was negatively associated with contemporary A. lumbricoides faecal egg counts before treatment. Following treatment, the pre-treatment T(H)2 cytokine expression data for younger hosts (now reflecting responsiveness 8-9 months in the past) were negatively associated with T. trichiura faecal egg counts. Taken together, these observations suggest a successional interaction between T(H)2-driven immune responses and species infection over time. However, any differential effects of the measured immune responses on species-specific recruitment, maturation and mortality were superimposed upon (and outweighed by) the effects of other factors favouring coinfection.lld:pubmed
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pubmed-article:15491586pubmed:articleTitleCytokine response profiles predict species-specific infection patterns in human GI nematodes.lld:pubmed
pubmed-article:15491586pubmed:affiliationSchool of Biology, Nottingham University, Nottingham NG7 2RD, UK.lld:pubmed
pubmed-article:15491586pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15491586pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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