Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-10-19
pubmed:abstractText
This study investigated associations between pre-treatment cytokine expression and infection patterns, before and after de-worming, in humans exposed to two gastrointestinal nematode species. Quantitative measures of Ascaris lumbricoides and Trichuris trichiura infection (based on faecal egg counts) were estimated immediately before and 8-9 months after treatment in a Cameroonian population. Whole blood cytokine responses to parasite-derived antigens were assayed immediately pre-treatment. An overall measure of the tendency towards species-specific infection (increasing with A. lumbricoides faecal egg counts and decreasing with T. trichiura faecal egg counts) was significantly positively related to IL-10 levels in older (14-57 year) hosts. There was a significant negative influence of IL-5 on reinfection probability in T. trichiura but not A. lumbricoides. This effect coincided with reduced reinfection success in T. trichiura compared to A. lumbricoides. T(H)2 cytokine expression by younger hosts (4-13 year) was negatively associated with contemporary A. lumbricoides faecal egg counts before treatment. Following treatment, the pre-treatment T(H)2 cytokine expression data for younger hosts (now reflecting responsiveness 8-9 months in the past) were negatively associated with T. trichiura faecal egg counts. Taken together, these observations suggest a successional interaction between T(H)2-driven immune responses and species infection over time. However, any differential effects of the measured immune responses on species-specific recruitment, maturation and mortality were superimposed upon (and outweighed by) the effects of other factors favouring coinfection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0020-7519
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1237-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15491586-Adolescent, pubmed-meshheading:15491586-Adult, pubmed-meshheading:15491586-Animals, pubmed-meshheading:15491586-Ascariasis, pubmed-meshheading:15491586-Ascaris lumbricoides, pubmed-meshheading:15491586-Child, pubmed-meshheading:15491586-Child, Preschool, pubmed-meshheading:15491586-Cytokines, pubmed-meshheading:15491586-Female, pubmed-meshheading:15491586-Gastrointestinal Diseases, pubmed-meshheading:15491586-Humans, pubmed-meshheading:15491586-Interleukin-10, pubmed-meshheading:15491586-Interleukin-13, pubmed-meshheading:15491586-Interleukin-5, pubmed-meshheading:15491586-Intestinal Diseases, Parasitic, pubmed-meshheading:15491586-Male, pubmed-meshheading:15491586-Middle Aged, pubmed-meshheading:15491586-Nematode Infections, pubmed-meshheading:15491586-Parasite Egg Count, pubmed-meshheading:15491586-Species Specificity, pubmed-meshheading:15491586-Trichuriasis, pubmed-meshheading:15491586-Trichuris
pubmed:year
2004
pubmed:articleTitle
Cytokine response profiles predict species-specific infection patterns in human GI nematodes.
pubmed:affiliation
School of Biology, Nottingham University, Nottingham NG7 2RD, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't