Source:http://linkedlifedata.com/resource/pubmed/id/15491586
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2004-10-19
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pubmed:abstractText |
This study investigated associations between pre-treatment cytokine expression and infection patterns, before and after de-worming, in humans exposed to two gastrointestinal nematode species. Quantitative measures of Ascaris lumbricoides and Trichuris trichiura infection (based on faecal egg counts) were estimated immediately before and 8-9 months after treatment in a Cameroonian population. Whole blood cytokine responses to parasite-derived antigens were assayed immediately pre-treatment. An overall measure of the tendency towards species-specific infection (increasing with A. lumbricoides faecal egg counts and decreasing with T. trichiura faecal egg counts) was significantly positively related to IL-10 levels in older (14-57 year) hosts. There was a significant negative influence of IL-5 on reinfection probability in T. trichiura but not A. lumbricoides. This effect coincided with reduced reinfection success in T. trichiura compared to A. lumbricoides. T(H)2 cytokine expression by younger hosts (4-13 year) was negatively associated with contemporary A. lumbricoides faecal egg counts before treatment. Following treatment, the pre-treatment T(H)2 cytokine expression data for younger hosts (now reflecting responsiveness 8-9 months in the past) were negatively associated with T. trichiura faecal egg counts. Taken together, these observations suggest a successional interaction between T(H)2-driven immune responses and species infection over time. However, any differential effects of the measured immune responses on species-specific recruitment, maturation and mortality were superimposed upon (and outweighed by) the effects of other factors favouring coinfection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0020-7519
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1237-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15491586-Adolescent,
pubmed-meshheading:15491586-Adult,
pubmed-meshheading:15491586-Animals,
pubmed-meshheading:15491586-Ascariasis,
pubmed-meshheading:15491586-Ascaris lumbricoides,
pubmed-meshheading:15491586-Child,
pubmed-meshheading:15491586-Child, Preschool,
pubmed-meshheading:15491586-Cytokines,
pubmed-meshheading:15491586-Female,
pubmed-meshheading:15491586-Gastrointestinal Diseases,
pubmed-meshheading:15491586-Humans,
pubmed-meshheading:15491586-Interleukin-10,
pubmed-meshheading:15491586-Interleukin-13,
pubmed-meshheading:15491586-Interleukin-5,
pubmed-meshheading:15491586-Intestinal Diseases, Parasitic,
pubmed-meshheading:15491586-Male,
pubmed-meshheading:15491586-Middle Aged,
pubmed-meshheading:15491586-Nematode Infections,
pubmed-meshheading:15491586-Parasite Egg Count,
pubmed-meshheading:15491586-Species Specificity,
pubmed-meshheading:15491586-Trichuriasis,
pubmed-meshheading:15491586-Trichuris
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pubmed:year |
2004
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pubmed:articleTitle |
Cytokine response profiles predict species-specific infection patterns in human GI nematodes.
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pubmed:affiliation |
School of Biology, Nottingham University, Nottingham NG7 2RD, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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