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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-18
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pubmed:abstractText |
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, correlates significantly with DNA hypomethylation in pericentromeric satellite regions, which is known to result in centromeric decondensation and enhanced chromosomal recombination in precancerous conditions and hepatocellular carcinomas (HCCs). We aimed to elucidate further the significance of DNMT3b4 during human hepatocarcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
636-44
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pubmed:dateRevised |
2010-5-21
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pubmed:meshHeading |
pubmed-meshheading:15490234-Carcinoma, Hepatocellular,
pubmed-meshheading:15490234-Chromosomal Instability,
pubmed-meshheading:15490234-DNA (Cytosine-5-)-Methyltransferase,
pubmed-meshheading:15490234-DNA Methylation,
pubmed-meshheading:15490234-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15490234-Humans,
pubmed-meshheading:15490234-Liver Neoplasms,
pubmed-meshheading:15490234-Precancerous Conditions,
pubmed-meshheading:15490234-RNA, Messenger,
pubmed-meshheading:15490234-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15490234-Transfection,
pubmed-meshheading:15490234-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
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pubmed:affiliation |
Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan. ykanai@ncc.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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