Source:http://linkedlifedata.com/resource/pubmed/id/15489011
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-10-18
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pubmed:abstractText |
Several reports have indicated that the cerebellum is involved in regulation of some non-somatic activities through the cerebellohypothalamic projections. Therefore, the modulatory effects of the cerebellar interpositus nucleus (IN) on neuronal activity of the paraventricular nucleus of the hypothalamus (PVN) was investigated in this study by using in vivo extracellular recording technique in rats. We recorded from 115 PVN neurons, 51 (44.3%) responded to the cerebellar IN stimulation. Of the responsive PVN neurons tested for their sensitivity to hypertensive and/or hyperosmotic stimulations, 66.7% (6/9) and 75.0% (6/8) responded to intravenous metaraminol and hypertonic saline administration, respectively. These results demonstrate that the cerebellar IN afferent inputs impinge on the PVN neurons, including those baroreflex-sensitive and osmoresponsive neurons, suggesting that the cerebellum may actively participate in the cardiovascular regulation and osmoregulation through the cerebellohypothalamic projections.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
370
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15489011-Action Potentials,
pubmed-meshheading:15489011-Adrenergic alpha-Agonists,
pubmed-meshheading:15489011-Animals,
pubmed-meshheading:15489011-Cell Count,
pubmed-meshheading:15489011-Cerebellar Nuclei,
pubmed-meshheading:15489011-Electric Stimulation,
pubmed-meshheading:15489011-Female,
pubmed-meshheading:15489011-Male,
pubmed-meshheading:15489011-Metaraminol,
pubmed-meshheading:15489011-Neural Pathways,
pubmed-meshheading:15489011-Neurons,
pubmed-meshheading:15489011-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:15489011-Rats,
pubmed-meshheading:15489011-Rats, Sprague-Dawley,
pubmed-meshheading:15489011-Saline Solution, Hypertonic
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pubmed:year |
2004
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pubmed:articleTitle |
Cerebellar interpositus nuclear inputs impinge on paraventricular neurons of the hypothalamus in rats.
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pubmed:affiliation |
Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Mailbox 426, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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