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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-3-9
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pubmed:abstractText |
Although a number of reports have investigated the effects of IL-6 family cytokines on prostate cell growth, there is limited information available identifying IL-6 inducible downstream effector genes and their function in growth control. Previous studies have demonstrated that IL-6 treatment results in the activation of signal transducer and activator of transcription3 (STAT3) in prostate cancer cells. The goal of this study was to investigate the influence of IL-6 treatment and activation of the Jak/STAT signal transduction pathway on C/EBPdelta gene expression and growth inhibition of human prostate cancer cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-delta,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CEBPD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-54
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15486993-Binding Sites,
pubmed-meshheading:15486993-Blotting, Northern,
pubmed-meshheading:15486993-Blotting, Western,
pubmed-meshheading:15486993-CCAAT-Enhancer-Binding Protein-delta,
pubmed-meshheading:15486993-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:15486993-Cell Line, Tumor,
pubmed-meshheading:15486993-Cell Proliferation,
pubmed-meshheading:15486993-DNA-Binding Proteins,
pubmed-meshheading:15486993-Enzyme Activation,
pubmed-meshheading:15486993-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15486993-Humans,
pubmed-meshheading:15486993-Interleukin-6,
pubmed-meshheading:15486993-Janus Kinase 2,
pubmed-meshheading:15486993-Male,
pubmed-meshheading:15486993-Mutagenesis, Insertional,
pubmed-meshheading:15486993-Promoter Regions, Genetic,
pubmed-meshheading:15486993-Prostatic Neoplasms,
pubmed-meshheading:15486993-Protein-Tyrosine Kinases,
pubmed-meshheading:15486993-Proto-Oncogene Proteins,
pubmed-meshheading:15486993-RNA, Messenger,
pubmed-meshheading:15486993-STAT3 Transcription Factor,
pubmed-meshheading:15486993-Signal Transduction,
pubmed-meshheading:15486993-Thymidine,
pubmed-meshheading:15486993-Trans-Activators,
pubmed-meshheading:15486993-Transcription Factors,
pubmed-meshheading:15486993-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells.
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pubmed:affiliation |
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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