Source:http://linkedlifedata.com/resource/pubmed/id/15486039
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-1-14
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pubmed:abstractText |
Animal studies suggest that prostanoids (i.e., such as prostacyclin) may sensitize or impair baroreceptor and/or baroreflex responsiveness depending on the site of administration and/or inhibition. We tested the hypothesis that acute inhibition of cyclooxygenase (COX), the rate-limiting enzyme in prostanoid synthesis, impairs baroreflex regulation of cardiac period (R-R interval) and muscle sympathetic nerve activity (MSNA) in humans and augments pressor reactivity. Baroreflex sensitivity (BRS) was determined at baseline (preinfusion) and 60 min after (postinfusion) intravenous infusion of a COX antagonist (ketorolac; 45 mg) (24 +/- 1 yr; n = 12) or saline (25 +/- 1 yr; n = 12). BRS was assessed by using the modified Oxford technique (bolus intravenous infusion of nitroprusside followed by phenylephrine). BRS was quantified as the slope of the linear portion of the 1) R-R interval-systolic blood pressure relation (cardiovagal BRS) and 2) MSNA-diastolic blood pressure relation (sympathetic BRS) during pharmacological changes in arterial blood pressure. Ketorolac did not alter cardiovagal (19.4 +/- 2.1 vs. 18.4 +/- 2.4 ms/mmHg preinfusion and postinfusion, respectively) or sympathetic BRS (-2.9 +/- 0.7 vs. -2.6 +/- 0.4 arbitrary units.beat(-1).mmHg(-1)) but significantly decreased a plasma biomarker of prostanoid generation (plasma thromboxane B2) by 53 +/- 11%. Cardiovagal BRS (21.3 +/- 3.8 vs. 21.2 +/- 3.0 ms/mmHg), sympathetic BRS (-3.4 +/- 0.3 vs. -3.2 +/- 0.2 arbitrary units.beat(-1).mmHg(-1)), and thromboxane B2 (change in -1 +/- 12%) were unchanged in the control (saline infusion) group. Pressor responses to steady-state incremental (0.5, 1.0, and 1.5 microg.kg(-1).min(-1)) infusion (5 min/dose) of phenylephrine were not altered by ketorolac (n = 8). Collectively, these data indicate that acute pharmacological antagonism of the COX enzyme does not impair BRS (cardiovagal or sympathetic) or augment pressor reactivity in healthy young adults.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/C06 RR-016499,
http://linkedlifedata.com/resource/pubmed/grant/CA-00207,
http://linkedlifedata.com/resource/pubmed/grant/DC-006459,
http://linkedlifedata.com/resource/pubmed/grant/HL-58503,
http://linkedlifedata.com/resource/pubmed/grant/HL-67624,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR-10732
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pubmed:keyword | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0363-6135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H737-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15486039-Adolescent,
pubmed-meshheading:15486039-Adult,
pubmed-meshheading:15486039-Baroreflex,
pubmed-meshheading:15486039-Blood Pressure,
pubmed-meshheading:15486039-Cyclooxygenase Inhibitors,
pubmed-meshheading:15486039-Female,
pubmed-meshheading:15486039-Humans,
pubmed-meshheading:15486039-Infusions, Intravenous,
pubmed-meshheading:15486039-Ketorolac,
pubmed-meshheading:15486039-Male,
pubmed-meshheading:15486039-Prostaglandins,
pubmed-meshheading:15486039-Sympathetic Nervous System,
pubmed-meshheading:15486039-Vagus Nerve
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pubmed:year |
2005
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pubmed:articleTitle |
Cyclooxygenase inhibition and baroreflex sensitivity in humans.
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pubmed:affiliation |
Department of Medicine (Cardiology), General Clinical Research Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-2390, USA. kmonahan@psu.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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