Linked Life Data

15484208

Source:http://linkedlifedata.com/resource/pubmed/id/15484208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-10-26
pubmed:abstractText
Fenfluramine (FEN) is a substituted amphetamine known for its anorectic effects, without the stimulatory or abuse potential associated with other amphetamine derivatives. FEN is a potent serotonin (5-HT) releaser and reuptake inhibitor and has been shown to cause depletions of 5-HT that can last days and even weeks after administration. Administration of FEN four times on a single day also causes a prolonged increase of corticosterone (CORT) that lasts approximately 72 h following the first FEN dose. This dosing regimen also produces deficits in sequential learning as measured in the Cincinnati water maze (CWM). Adrenalectomy blocks this effect but removes more than CORT. Accordingly, the purpose of this study was to determine whether inhibiting glucocorticoid production, by administration of the 11 beta-hydroxylase inhibitor metyrapone (MET), will similarly attenuate or eliminate the sequential learning deficits seen with FEN exposure. MET (50 mg/kg) injections were administered 90 min prior to and for 3 days after FEN (four doses given at 2-h intervals). Animals pretreated with MET and treated with FEN showed no sequential learning deficits when tested 1 week following FEN administration compared to FEN alone. The depletions of monoamines were similar following FEN administration, regardless of MET treatment. Taken together, this suggests that a potential mechanism for the sequential learning deficits in FEN-treated animals is a result of prolonged increases in CORT output.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0887-4476
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
214-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15484208-Adrenal Glands, pubmed-meshheading:15484208-Age Factors, pubmed-meshheading:15484208-Animals, pubmed-meshheading:15484208-Biogenic Monoamines, pubmed-meshheading:15484208-Body Temperature, pubmed-meshheading:15484208-Body Weight, pubmed-meshheading:15484208-Enzyme Inhibitors, pubmed-meshheading:15484208-Fenfluramine, pubmed-meshheading:15484208-Hydroxyindoleacetic Acid, pubmed-meshheading:15484208-Hypothalamus, pubmed-meshheading:15484208-Learning Disorders, pubmed-meshheading:15484208-Male, pubmed-meshheading:15484208-Maze Learning, pubmed-meshheading:15484208-Metyrapone, pubmed-meshheading:15484208-Norepinephrine, pubmed-meshheading:15484208-Organ Size, pubmed-meshheading:15484208-Rats, pubmed-meshheading:15484208-Rats, Sprague-Dawley, pubmed-meshheading:15484208-Serotonin, pubmed-meshheading:15484208-Serotonin Uptake Inhibitors, pubmed-meshheading:15484208-Swimming, pubmed-meshheading:15484208-Thymus Gland
pubmed:year
2004
pubmed:articleTitle
Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.
pubmed:affiliation
Division of Developmental Biology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.