Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-4-22
|
| pubmed:abstractText |
Previous studies in the mouse have strongly implicated colony-stimulating factor-1 (CSF-1) in the regulation of placental development. In this study of human pregnancy, we detected CSF-1 in serum, endometrium, placenta, chorion, amnion, and amniotic fluid, with significant increases in serum and endometrial samples from the first trimester compared to levels in nonpregnant controls. CSF-1 mRNA was demonstrated in all of these tissues, except amnion, with a significant increase within the first trimester endometrial samples over nonpregnant control values. In addition to the major 4.0-kilobase mRNA, other species of CSF-1 mRNA were detected, which were shown to be due to alternative splicing within exon 6 and the alternative use of exon 9 or 10. In the endometrium, CSF-1 was localized to glandular epithelial and endothelial cells. In first trimester placenta, CSF-1 was in the cytotrophoblasts lining the villous core and in the cytotrophoblastic shell. During the second trimester, CSF-1 was localized to villous mesenchymal cells. By the third trimester, CSF-1 was only detected in cells lining the villous vessels. The detection of CSF-1 during gestation strongly supports a role for CSF-1 in the regulation of placental function in humans by autocrine and/or paracrine mechanisms.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
850-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1548350-Amnion,
pubmed-meshheading:1548350-Amniotic Fluid,
pubmed-meshheading:1548350-Base Sequence,
pubmed-meshheading:1548350-Blotting, Northern,
pubmed-meshheading:1548350-Chorion,
pubmed-meshheading:1548350-Endometrium,
pubmed-meshheading:1548350-Female,
pubmed-meshheading:1548350-Gene Expression,
pubmed-meshheading:1548350-Humans,
pubmed-meshheading:1548350-Immunohistochemistry,
pubmed-meshheading:1548350-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:1548350-Molecular Sequence Data,
pubmed-meshheading:1548350-Placenta,
pubmed-meshheading:1548350-Polymerase Chain Reaction,
pubmed-meshheading:1548350-RNA, Messenger,
pubmed-meshheading:1548350-Radioimmunoassay,
pubmed-meshheading:1548350-Transcription, Genetic,
pubmed-meshheading:1548350-Uterus
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Expression of colony-stimulating factor-1 in the human uterus and placenta.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|