Linked Life Data

15483381

Source:http://linkedlifedata.com/resource/pubmed/id/15483381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2004-10-14
pubmed:abstractText
Carbohydrate-carbohydrate recognition is emerging today as an important type of interaction in cell adhesion. One Ca(2+)mediated homotypic interaction between two Lewis( X ) determinants (Le( X )) has been proposed to drive cell adhesion in murine embryogenesis. Here, the adhesion energies of lipid vesicles functionalized with glycolipids bearing monomeric or dimeric Le( X ) determinants were measured in NaCl or CaCl(2) media with the micropipette aspiration technique. These experiments on Le( X ) with an environment akin to that provided by biological membrane confirmed the existence of this specific calcium dependent interaction of monomeric Le( X ). In contrast, dimeric Le( X ) produced a repulsive contribution. By using a simple model involving the various contributions to the adhesion free energy, specific and non specific interactions could be separated and quantified. The involvement of calcium ions has been discussed in the monomeric and dimeric Le( X ) lipids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0282-0080
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-74
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Specific and non specific interactions involving Le( X ) determinant quantified by lipid vesicle micromanipulation.
pubmed:affiliation
Laboratoire de Physique Statistique de l'Ecole Normale Supérieure, UMR 8550 associée au CNRS et aux universités Paris 6 et Paris 7, France.
pubmed:publicationType
Journal Article