Linked Life Data

15483182

Source:http://linkedlifedata.com/resource/pubmed/id/15483182

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-10-14
pubmed:abstractText
Neospora caninum has been reported to be an important cause of endemic fetal loss and occasional abortion epidemics in cattle around the world. This study examined 12,016 sera collected from 9723 Holstein cows on 125 herds across Ontario in 1998, 1999, and 2000. An enzyme-linked immunosorbent assay was used to examine the sera for antibodies to N. caninum. The overall prevalence of N. caninum antibodies in the cattle was 11.2% and the prevalence in individual herds varied from 0 to 70.4%. Among 3109 daughter-dam pairs, 619 positive dams had 252 positive daughters, giving a detected vertical transmission rate of 40.7%. In contrast, there were only 6.7% positive daughters from negative dams (167 of 2490). Pedigree edits left 8031 cows with 1463 sires for estimation of heritability. Five genetic models (sire model, animal model, sire-dam model, a sire-maternal grandsire model, and a maternal effects model) with fixed effects of bleeding year-month, age of the animals, and herd were fitted to the data. The estimated heritability of susceptibility to N. caninum ranged between 0.084 and 0.124. The sire-maternal grandsire model and the maternal effects model provided better fit than the other models because the maternal genetic variance was much greater than the direct genetic variance. To reduce the incidence of N. caninum infection, more emphasis should be placed on management practices than on genetic selection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0302
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3967-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Genetic susceptibility to Neospora caninum infection in Holstein cattle in Ontario.
pubmed:affiliation
CGIL, Department of Animal and Poultry Science, University of Guelph, Ontario, Canada N1G 2W1.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't