Source:http://linkedlifedata.com/resource/pubmed/id/15483090
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-1-11
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pubmed:abstractText |
Graves' disease (GD) is an autoimmune disorder with genetic predisposition. IL-13 is an important mediator of antiinflammatory immune responses and is expressed in the thyroid and orbit. The aim of the present study was to investigate whether IL-13 gene polymorphisms are associated with the development of GD. IL-13 gene polymorphisms were studied in Japanese GD patients (n = 310) and healthy control subjects without antithyroid autoantibodies or a family history of autoimmune disorders (n = 244). A C/T polymorphism at position -1112 of the promoter region was measured using the direct sequencing method, and an Arg(130)Gln (G2044A) polymorphism in exon 4 was examined using the PCR-restriction fragment length polymorphism method. There was a significant decrease in -1112T allele frequency in GD patients compared with controls (16% vs. 23%; P = 0.0019). The frequency of the 2044A allele on exon 4 also appeared lower in GD patients compared with controls. Haplotype analysis showed a significant decrease in the -1112T/2044A haplotype in GD patients. There was no association between IL-13 gene polymorphisms and ophthalmopathy, severity, or serum IgE levels. In conclusion, IL-13 gene polymorphisms are associated with GD susceptibility in Japan.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296-301
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15483090-Adolescent,
pubmed-meshheading:15483090-Adult,
pubmed-meshheading:15483090-Aged,
pubmed-meshheading:15483090-Aged, 80 and over,
pubmed-meshheading:15483090-Asian Continental Ancestry Group,
pubmed-meshheading:15483090-Child,
pubmed-meshheading:15483090-Female,
pubmed-meshheading:15483090-Genetic Predisposition to Disease,
pubmed-meshheading:15483090-Graves Disease,
pubmed-meshheading:15483090-Humans,
pubmed-meshheading:15483090-Immunoglobulin E,
pubmed-meshheading:15483090-Interleukin-13,
pubmed-meshheading:15483090-Male,
pubmed-meshheading:15483090-Middle Aged,
pubmed-meshheading:15483090-Polymorphism, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.
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pubmed:affiliation |
Department of Endocrinology and Metabolism, Kurume University School of Medicine, 67 Asahimatchi, Kurume, Fukuoka 830-0011, Japan. yuji@med.kurume-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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