Source:http://linkedlifedata.com/resource/pubmed/id/15482825
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2004-10-14
|
| pubmed:abstractText |
A photo-reactive polymer having a phospholipid polar group was prepared, and the polymer was photo-immobilized on polymeric surfaces, where its interactions with biocomponents were investigated. By using a photo-immobilization method, the polymer was used for surface modification of polyethylene and polypropylene, polymers whose surfaces were not treated in our previous development of the phosphorylcholine-derived polymer. The photo-reactive polymer was synthesized by a coupling reaction involving copolymer consisting of 2-methacryloyloxyethyl phosphorylcholine and methacrylic acid with 4-azidoaniline. When the polymer was unpattern immobilized on the surface, X-ray photo-electron spectroscopic analysis and static contact angle measurements were performed. It was shown that the surface was covered with phospholipid polar groups. Micropattern immobilization was carried out using a micropatterned photo-mask. Measurements using atomic force microscopy showed that the swelled micropatterned polymer was five times as thick as the dried one. Protein adsorption and platelet adhesion were reduced on the polymer-immobilized regions. Mammalian cells did not adhere, and formed aggregates on the immobilized regions. In conclusion, the photo-reactive phospholipid polymer was covalently immobilized on the conventional polymer surfaces and it tended to reduce interactions with proteins and cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene,
http://linkedlifedata.com/resource/pubmed/chemical/Polypropylenes,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Bovine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0142-9612
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1381-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15482825-Adsorption,
pubmed-meshheading:15482825-Animals,
pubmed-meshheading:15482825-Cell Adhesion,
pubmed-meshheading:15482825-Cells, Cultured,
pubmed-meshheading:15482825-Coated Materials, Biocompatible,
pubmed-meshheading:15482825-Humans,
pubmed-meshheading:15482825-Immunoglobulins,
pubmed-meshheading:15482825-Light,
pubmed-meshheading:15482825-Materials Testing,
pubmed-meshheading:15482825-Mice,
pubmed-meshheading:15482825-Monocytes,
pubmed-meshheading:15482825-Phospholipids,
pubmed-meshheading:15482825-Photochemistry,
pubmed-meshheading:15482825-Platelet Adhesiveness,
pubmed-meshheading:15482825-Polyethylene,
pubmed-meshheading:15482825-Polypropylenes,
pubmed-meshheading:15482825-Protein Binding,
pubmed-meshheading:15482825-Serum Albumin, Bovine,
pubmed-meshheading:15482825-Surface Properties,
pubmed-meshheading:15482825-Tissue Engineering
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Photo-immobilization of a phospholipid polymer for surface modification.
|
| pubmed:affiliation |
Regenerative Medical Bioreactor Project, Kanagawa Academy of Science and Technology, KSP East 309, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|