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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-10-14
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pubmed:abstractText |
Dysfunction of neuronal signal transduction via G-protein has previously been speculated to be involved in the pathophysiology of schizophrenia. Regulator of G-protein signaling (RGS) is a protein that acts as a GTPase-activator for Galpha protein. A total of 33 Japanese patients with schizophrenia were screened for mutations in the coding region of the RGS10 gene, and a novel missense polymorphism (Val38Met) in the RGS domain was detected. A case-control study did not reveal a significant association between this polymorphism and schizophrenia. The results do not provide evidence that the RGS10 gene is involved in biological vulnerability to schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1323-1316
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
579-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15482592-Adult,
pubmed-meshheading:15482592-Aged,
pubmed-meshheading:15482592-Alleles,
pubmed-meshheading:15482592-Amino Acid Substitution,
pubmed-meshheading:15482592-Case-Control Studies,
pubmed-meshheading:15482592-Chromosomes, Human, Pair 10,
pubmed-meshheading:15482592-Female,
pubmed-meshheading:15482592-Gene Frequency,
pubmed-meshheading:15482592-Genetic Predisposition to Disease,
pubmed-meshheading:15482592-Genetic Testing,
pubmed-meshheading:15482592-Genotype,
pubmed-meshheading:15482592-Humans,
pubmed-meshheading:15482592-Japan,
pubmed-meshheading:15482592-Male,
pubmed-meshheading:15482592-Middle Aged,
pubmed-meshheading:15482592-Mutation, Missense,
pubmed-meshheading:15482592-Open Reading Frames,
pubmed-meshheading:15482592-Polymorphism, Genetic,
pubmed-meshheading:15482592-RGS Proteins,
pubmed-meshheading:15482592-Risk Factors,
pubmed-meshheading:15482592-Schizophrenia,
pubmed-meshheading:15482592-Schizophrenic Psychology
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pubmed:year |
2004
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pubmed:articleTitle |
Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia.
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pubmed:affiliation |
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan.
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pubmed:publicationType |
Journal Article
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