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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-10-14
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pubmed:abstractText |
The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the cytotoxic effect of alkylating agents on tumor cells. The presence of two nonconsensus glucocorticoid-responsive elements in the human MGMT promoter region indicates the potential regulation of MGMT expression by glucocorticoid agents. This study was performed to elucidate whether dexamethasone affects the expression of MGMT in glioblastoma multiforme (GBM) cells, thereby limiting the benefit of chemotherapeutic alkylating agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
659-63
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:15481722-Antineoplastic Agents,
pubmed-meshheading:15481722-Antineoplastic Agents, Hormonal,
pubmed-meshheading:15481722-Brain Neoplasms,
pubmed-meshheading:15481722-Dexamethasone,
pubmed-meshheading:15481722-Drug Resistance, Neoplasm,
pubmed-meshheading:15481722-Enzyme Induction,
pubmed-meshheading:15481722-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15481722-Glioblastoma,
pubmed-meshheading:15481722-Humans,
pubmed-meshheading:15481722-Nimustine,
pubmed-meshheading:15481722-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:15481722-RNA, Messenger,
pubmed-meshheading:15481722-Tumor Cells, Cultured,
pubmed-meshheading:15481722-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas.
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pubmed:affiliation |
Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan. uedas@post.saga-med.ac.jp
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pubmed:publicationType |
Journal Article
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