| pubmed-article:15480852 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15480852 | lifeskim:mentions | umls-concept:C0016719 | lld:lifeskim |
| pubmed-article:15480852 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:15480852 | lifeskim:mentions | umls-concept:C0150097 | lld:lifeskim |
| pubmed-article:15480852 | lifeskim:mentions | umls-concept:C0010286 | lld:lifeskim |
| pubmed-article:15480852 | lifeskim:mentions | umls-concept:C0087163 | lld:lifeskim |
| pubmed-article:15480852 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15480852 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15480852 | pubmed:abstractText | Impaired oxidative phosphorylation is a crucial factor in the pathogenesis of Friedreich's ataxia (FA). L-carnitine and creatine are natural compounds that can enhance cellular energy transduction. We performed a placebo-controlled triple-phase crossover trial of L-carnitine (3 g/d) and creatine (6.75 g/d) in 16 patients with genetically confirmed FA. Primary outcome measures were mitochondrial ATP production measured as phosphocreatine recovery by 31Phosphorus magnetic resonance spectroscopy, neurological deficits assessed by the international co-operative ataxia rating scale and cardiac hypertrophy in echocardiography. After 4 months on L-carnitine phosphocreatine recovery was improved compared to baseline (p<0.03, t-test) but comparison to placebo and creatine effects did not reach significance (p=0.06, F-test). Ataxia rating scale and echocardiographic parameters remained unchanged. Creatine had no effect in FA patients. L-carnitine is a promising substance for the treatment of FA patients, and larger trials are warranted. | lld:pubmed |
| pubmed-article:15480852 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15480852 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15480852 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15480852 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15480852 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15480852 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15480852 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15480852 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15480852 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15480852 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:MüllerKK | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:PrzuntekHH | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:AbeleMM | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:KlockgetherTT | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:SchölsLL | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:VorgerdMM | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:ZangeJJ | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:SkipkaGG | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:Kuntz-HehnerS... | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:SchillingsMM | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:15480852 | pubmed:author | pubmed-author:ColierW N J... | lld:pubmed |
| pubmed-article:15480852 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15480852 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:15480852 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15480852 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15480852 | pubmed:pagination | 789-96 | lld:pubmed |
| pubmed-article:15480852 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15480852 | pubmed:meshHeading | pubmed-meshheading:15480852... | lld:pubmed |
| pubmed-article:15480852 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15480852 | pubmed:articleTitle | L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial. | lld:pubmed |
| pubmed-article:15480852 | pubmed:affiliation | Centre of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany. ludger.schoels@uni-tuebingen.de | lld:pubmed |
| pubmed-article:15480852 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15480852 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15480852 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:15480852 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15480852 | lld:pubmed |
