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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-4-23
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pubmed:abstractText |
A murine experimental infection with a hemolysin-producing (Hly+) strain of Listeria monocytogenes and a non-hemolysin-producing (Hly-) mutant was used as an in vivo model to evaluate the role of hemolysin production in the immune response. No antilisterial antibodies were detectable following sublethal infection with Hly+ bacteria, but consistent antilisterial immunoglobulin G (IgG) and IgM antibody production was observed following sublethal infection with the Hly- mutant. Hly+ but not Hly- L. monocytogenes induced transient inhibition of antibody response to Hly- bacteria and to unrelated T-cell-dependent (tetanus toxoid) and T-cell-independent (pneumococcal polysaccharide 3) antigens. Transient inhibition of the activation of an antigen-specific T-cell clone was also observed following Hly+ infection of antigen-presenting cells but not following Hly- infection. These results suggest that hemolysin production by L. monocytogenes is an important factor in modulating the immune response to T-cell-dependent and T-cell-independent antigens in infected individuals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1548067-13341822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1548067-13715686,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1548067-849655
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1415-21
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1548067-Animals,
pubmed-meshheading:1548067-Antibody Formation,
pubmed-meshheading:1548067-Antigen-Presenting Cells,
pubmed-meshheading:1548067-Antigens, Bacterial,
pubmed-meshheading:1548067-Blotting, Western,
pubmed-meshheading:1548067-Disease Models, Animal,
pubmed-meshheading:1548067-Dose-Response Relationship, Immunologic,
pubmed-meshheading:1548067-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1548067-Female,
pubmed-meshheading:1548067-Hemolysin Proteins,
pubmed-meshheading:1548067-Immunoglobulin G,
pubmed-meshheading:1548067-Immunosuppression,
pubmed-meshheading:1548067-Lethal Dose 50,
pubmed-meshheading:1548067-Listeria monocytogenes,
pubmed-meshheading:1548067-Mice,
pubmed-meshheading:1548067-Mice, Inbred C57BL,
pubmed-meshheading:1548067-Polysaccharides, Bacterial,
pubmed-meshheading:1548067-Spleen,
pubmed-meshheading:1548067-T-Lymphocytes,
pubmed-meshheading:1548067-Tetanus Toxoid,
pubmed-meshheading:1548067-Time Factors,
pubmed-meshheading:1548067-Virulence
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pubmed:year |
1992
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pubmed:articleTitle |
Hemolysin-producing Listeria monocytogenes affects the immune response to T-cell-dependent and T-cell-independent antigens.
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pubmed:affiliation |
Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland.
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pubmed:publicationType |
Journal Article
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