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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
20
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|
pubmed:dateCreated |
2004-10-13
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|
pubmed:abstractText |
9-Mer DNA sequences containing 2'-N-methyl-2'-N-(pyren-1-ylmethyl)-2'-amino-DNA monomers display significantly increased affinity towards DNA complements whereas the corresponding 2'-amino-DNA monomer has a detrimental effect on duplex stability. These effects are efficiently reversed by incorporation of four LNA nucleotides inducing a B-DNA to A-DNA conformational change.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1477-0520
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2885-7
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|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
|
|
pubmed:year |
2004
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|
pubmed:articleTitle |
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.
|
|
pubmed:affiliation |
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Denmark.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
