| pubmed-article:1548034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1548034 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1548034 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1548034 | pubmed:dateCreated | 1992-4-23 | lld:pubmed |
| pubmed-article:1548034 | pubmed:abstractText | We have reported previously that macrophages obtained from renal patients on continuous ambulatory peritoneal dialysis (CAPD) during an episode of infectious peritonitis display a decrease in intracellular cAMP levels and in spontaneous in vitro release of PGE2 and PGI2. Such macrophages also release large quantities of IL-1 beta and TNF alpha when stimulated in vitro by LPS. In view of the interregulatory effects between PGE2 and macrophage cytokines (IL-1 beta and TNF alpha) in their production, we examined in the present work to what extent the LPS-induced release of either IL-1 beta or TNF alpha in vitro from CAPD-originated peritoneal macrophages is affected by graded doses of exogenous PGE2 (range 0-1000 ng/ml) and by the cyclooxygenase inhibitor indomethacin (INDO) (10(-6) M). IL-1 beta and TNF alpha were determined using an enzyme-linked immunoabsorbent assay and an immunoradiometric assay, respectively. We found that PGE2 invariably induced a dose-dependent decrease in TNF alpha release. In peritoneal macrophages collected during an infection-free period, TNF alpha release decreased from 3225 pg/ml (controls) to 353 pg/ml at 1000 ng/ml of PGE2, and in peritoneal macrophages collected during an episode of infectious peritonitis, it decreased from 4100 pg/ml (controls) to 545 pg/ml at 100 ng/ml of PGE2. However, PGE2 failed to influence the secretion of IL-1 beta. INDO induced an approx. two-fold increase in TNF alpha release, but had no effect on IL-1 beta release. These findings indicate that exogenous and endogenous PGE2 controls the release of TNF alpha rather than IL-1 beta from LPS-stimulated peritoneal macrophages. | lld:pubmed |
| pubmed-article:1548034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1548034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1548034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1548034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1548034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1548034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1548034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1548034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1548034 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1548034 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:1548034 | pubmed:author | pubmed-author:BontaI LIL | lld:pubmed |
| pubmed-article:1548034 | pubmed:author | pubmed-author:Ben-EfraimSS | lld:pubmed |
| pubmed-article:1548034 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:1548034 | pubmed:author | pubmed-author:FierenM WMW | lld:pubmed |
| pubmed-article:1548034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1548034 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:1548034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1548034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1548034 | pubmed:pagination | 85-90 | lld:pubmed |
| pubmed-article:1548034 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
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| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
| pubmed-article:1548034 | pubmed:meshHeading | pubmed-meshheading:1548034-... | lld:pubmed |
| pubmed-article:1548034 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1548034 | pubmed:articleTitle | Prostaglandin E2 inhibits the release of tumor necrosis factor-alpha, rather than interleukin 1 beta, from human macrophages. | lld:pubmed |
| pubmed-article:1548034 | pubmed:affiliation | Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:1548034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1548034 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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