Linked Life Data

15479862

Source:http://linkedlifedata.com/resource/pubmed/id/15479862

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
254
pubmed:dateCreated
2004-10-13
pubmed:abstractText
Caspases, the cysteine proteases that cleave their substrates following an aspartate residue, primarily carry out two distinct functions: (i) activation of proinflammatory cytokines and (ii) execution of apoptosis. These two functions are considered to be unique to individual caspases; thus, some caspases act in apoptosis, whereas others have a role in inflammation. However, this dogma is now being challenged as nonapoptotic functions are ascribed to caspases that, until recently, were only known to function in cell death pathways. Recent work suggests that DRONC, the only initiator cell death caspase in Drosophila, may play a direct or indirect role in cell migration, sperm differentiation, and cell proliferation in addition to its function in cell death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1525-8882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
2004
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe49
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical "apoptotic caspase".
pubmed:affiliation
Hanson Institute, Institute of Medical and Veterinary Science, P.O. Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia. sharad.kumar@imvs.sa.gov.au <sharad.kumar@imvs.sa.gov.au>
pubmed:publicationType
Journal Article, Review