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rdf:type |
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lifeskim:mentions |
umls-concept:C0015176,
umls-concept:C0026882,
umls-concept:C0032150,
umls-concept:C0162643,
umls-concept:C0220908,
umls-concept:C0370215,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0683598,
umls-concept:C0699788,
umls-concept:C0939219,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
9
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pubmed:dateCreated |
2004-10-12
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pubmed:abstractText |
Two single-point mutations of the Plasmodium falciparum cytochrome b gene (Tyr268Asn and Tyr268Ser) were recently reported in cases of atovaquone/proguanil (Malarone) treatment failure. However, little is known about the prevalence of codon-268 mutations and their quantitative association with treatment failure.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Atovaquone,
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes b,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Proguanil,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/malarone
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:AlifrangisMichaelM,
pubmed-author:BeranJiriJ,
pubmed-author:BisoffiZenoZ,
pubmed-author:CuadrosJuanJ,
pubmed-author:EhrhardtStephanS,
pubmed-author:European Network on Surveillance of Imported Infectious Diseases,
pubmed-author:FryGrahamG,
pubmed-author:GasconJoaquimJ,
pubmed-author:GjorupIdaI,
pubmed-author:GrobuschMartin PMP,
pubmed-author:HatzChristophC,
pubmed-author:JelinekTomasT,
pubmed-author:KernPeterP,
pubmed-author:KollaritschHerwigH,
pubmed-author:LaferlHermannH,
pubmed-author:MatteelliAlbertoA,
pubmed-author:McWhinneyPaulP,
pubmed-author:MuehlbergerNikolaiN,
pubmed-author:MuhlenMarionM,
pubmed-author:Peyerl-HoffmannGabrieleG,
pubmed-author:RichterJoachimJ,
pubmed-author:SchulzeMarcoM,
pubmed-author:WichmannOleO,
pubmed-author:da CunhaSaraivaS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1541-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15478057-Adolescent,
pubmed-meshheading:15478057-Adult,
pubmed-meshheading:15478057-Aged,
pubmed-meshheading:15478057-Amino Acid Substitution,
pubmed-meshheading:15478057-Animals,
pubmed-meshheading:15478057-Antimalarials,
pubmed-meshheading:15478057-Atovaquone,
pubmed-meshheading:15478057-Codon,
pubmed-meshheading:15478057-Cytochromes b,
pubmed-meshheading:15478057-DNA, Protozoan,
pubmed-meshheading:15478057-Drug Combinations,
pubmed-meshheading:15478057-Drug Resistance,
pubmed-meshheading:15478057-Europe,
pubmed-meshheading:15478057-Female,
pubmed-meshheading:15478057-Genes, Protozoan,
pubmed-meshheading:15478057-Humans,
pubmed-meshheading:15478057-Malaria, Falciparum,
pubmed-meshheading:15478057-Male,
pubmed-meshheading:15478057-Middle Aged,
pubmed-meshheading:15478057-Molecular Epidemiology,
pubmed-meshheading:15478057-Mutation, Missense,
pubmed-meshheading:15478057-Naphthoquinones,
pubmed-meshheading:15478057-Plasmodium falciparum,
pubmed-meshheading:15478057-Point Mutation,
pubmed-meshheading:15478057-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15478057-Proguanil,
pubmed-meshheading:15478057-Protozoan Proteins,
pubmed-meshheading:15478057-Treatment Failure
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pubmed:year |
2004
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pubmed:articleTitle |
Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.
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pubmed:affiliation |
Institute of Tropical Medicine, Charité, Humboldt University, Berlin, Germany. ole.wichmann@charite.de.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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